Games like The Binding of Isaac

"Enter the Gungeon" is a fast-paced bullet hell roguelike game. You play as a character entering a constantly changing gun-themed dungeon, fighting against various enemies and bosses with an arsenal of creative and powerful weapons. The goal is to find the ultimate weapon to defeat your past. With procedurally generated levels and a wide range of items, no two runs are the same.

"Risk of Rain is a 2D action roguelike game with randomized stages, enemies, and permadeath. Players can find over 100 items to help them fight through hordes of monsters and bosses as they search for the teleporter to escape the planet. The game features online co-op for up to 4 players. Each run offers a new, challenging experience with its procedurally generated content."

"Rogue Legacy" is a procedurally generated action-platformer game where you control a succession of unique characters from a single family tree. Traits such as OCD, poor vision, or sexual orientation are randomly assigned to each new character upon death, adding a layer of replayability and unpredictability. Choose your heirs wisely and manage your gold strategically to delve deeper into the castle and uncover its secrets.

Crypt of the NecroDancer is a rhythm-based dungeon crawler game. Players move and attack in time with the beat while exploring levels filled with monsters and loot. Permadeath adds a challenging twist, requiring players to master the rhythm and strategize their movements to defeat the NecroDancer.

Dead Cells is a RogueVania game, combining the progressive exploration of a Metroidvania with the replayability of a rogue-lite and the challenging combat of a souls-like. With over 150 weapons and spells, players will face permadeath while navigating through an interconnected world with multiple areas to explore. Nonlinear progression allows for choice in route and permanent abilities to unlock new paths.

"Hammerwatch is a Fantasy Hack and Slash game with outstanding graphics, stellar music, and exceptional gameplay. Play solo or with up to four players in local, online, or LAN co-op. Customize your experience with adjustable difficulty, character development, and unlockable skills. With mod and editing support, there's lots of replayability in this action-adventure game."

"Super House of Dead Ninjas" is an action-packed arcade game with roguelite elements and randomly generated levels, offering endless replayability. Play as the Crimson Ninja, wielding a variety of weapons and magic, and battle your way down a 30-second timer-driven tower filled with enemies and traps. The game features new enemies, hazards, achievements, and controller support in its Steam version, encouraging leaderboard competition.

"Caveblazers is a fantasy platformer roguelike offering both single-player and local co-op mode for 2 players. The game generates procedurally leveled caves to explore, filled with a vast array of weapons, equipment, and monsters. With smart AI characters, online multiplayer mod, and high replayability, Caveblazers provides delightful game mechanics, outstanding visuals, and a good soundtrack, though it involves plenty of grinding and humor."

"Rampage Knights" is a cooperative beat 'em up game with randomized dungeon crawling, where you can play alone or with a friend online. Fight your way through a labyrinth of monsters and traps in a ruined castle to face its sinister master. Your hero gains new abilities and powers as you progress, with frenetic action inspired by Golden Axe and Binding of Isaac.

UnderMine is a single-player Role Playing game with an intriguing story, spectacular gameplay, and amazing graphics. As you delve deep into the dungeon, discover its secrets and mine gold, while upgrading yourself with relics, potions, prayers, blessings, and curses. Rescue friendly characters for powerful upgrades and challenge dangerous bosses to unfold the mystery at the heart of the dungeon. The game is very replayable, with a hilarious tone and a lot of grinding.