Games like SynthetiCell BioClicker

Clickyland is a single-player Fantasy Strategy game with about 18 hours of playtime, where you defend your castle, harvest resources, and fight enemies by clicking on objects and structures. The game features procedural tower defense levels, over 35 unlockable buildings and upgrades, and over 30 unique enemies to encounter. Progressively stronger enemies will test your survival skills as you aim to reach day 100.

"Land of the Vikings" is fun settlement management game where you chop trees, farm, mine, and fish to survive harsh winters and expand your village. Each villager has unique characteristics, making them better suited to certain tasks than others. The game also features unpredictable weather events and natural disasters that you'll need to prepare for to keep your settlement thriving. As your settlement grows, you can welcome new Vikings to join and start families, strengthening your lineage and community.

SteamWorld Build is a single-player Science Fiction 4X game with an intriguing story and wonderful gameplay. As you collect resources and build a new home to save your town, you'll encounter crotchety steamfolk and ancient tech. With stunning graphics, a good soundtrack, and the need for lots of grinding, this game will keep you engaged as you stare into the abyss and dig for riches. Join the SteamWorld Build Community on Discord for updates and support.

In Super Fantasy Kingdom, you must rebuild your homeland after it’s destroyed and defend against nightly monster invasions. Each run allows you to carry over rewards, unlock new heroes, and explore previously hidden lands while facing increasingly fierce foes and powerful bosses. Uncover the mystery behind the endless cycle of life, death, and defense.

Stacklands is a village-building game where you stack cards to collect resources, construct buildings, and battle creatures. Cards can be sold for coins to buy packs containing themed cards that expand your village. At the end of each moon, ensure your villagers have enough food, or they will starve. The game features over 200 cards, 60 ideas, and 50 quests, with combat against goblins, bears, and rats.

"Microcivilization is a single-player strategy game with sensational pixel-art graphics, offering a unique blend of exploration, expansion, exploitation, and extermination. Build a powerful nation using various methods, such as button smashing or harnessing the productivity of your people. Overcome numerous challenges, including disasters, wars, diseases, and social unrest, with the help of government combinations, unique heroes, and technology upgrades."

"The Universim" is a god-game simulation where players oversee a developing civilization across time. Manage resources, research technology, and handle natural disasters to guide your civilization to prosperity. Experience a living, breathing world with dynamic AI and simulated ecosystems. However, keep in mind that ultimate power may lead to the downfall of your civilizations if misused.

Synergy is a single-player strategy game with compelling mechanics and fabulous graphics. As a governor, your goal is to build a city for your citizens in a strange yet mesmerizing environment. You'll need to analyze the natural elements, conduct research, and ensure the safety and prosperity of your city through sustainable approaches, all while adapting to the unforgiving environment.

In "Galactic Mining Corp," manage your own space mining operation, colonizing planets and managing resources to expand your business. Extract valuable resources, research new technologies, and defend against alien threats in this strategy game. With procedurally generated planets and a variety of mining vehicles, each playthrough offers a new and unique challenge.

In Spellcaster University, you manage a magical school, recruiting teachers and building a unique institution shaped by your chosen magic styles. Customize your university as a hub for black magic, nature magic, or combat training, while defending against orc attacks and navigating strict education controls. Utilize dynamic magic deck mechanics to shape every playthrough with new spells, artifacts, and challenges.