Games like Powerhouse of the Cell

75%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:graphics, grinding

75% User Score Based on 128 reviews

Interact with elements and molecules in a way that you have never before! Observe them and make them react with each other in the sandbox mode. Synthesize every molecule in the quest mode. Discover countless macromolecules and the elegancy of chemistry. If you enjoyed this game, see our list of games similar to Project Chemistry.

94%Game Brain Score

Most mentioned positive aspects:graphics, optimization

Most mentioned negative aspects:gameplay, story

94% User Score Based on 376 reviews

Virtual Circuit Board is the minimalist drawing-based logic simulator where you will design, program, decorate, and simulate anything from simple monochrome circuits to complex and colorful computers. Explore your creativity in this sandbox experience. If you enjoyed this game, see our list of games similar to Virtual Circuit Board.

86%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

86% User Score Based on 85 reviews

Survive and evolve as an organism with this simulation game in which you will literally start as a single cell and manage and organize all its functions to a fully fledged system! Assemble, breathe, eat, fight threats, produce energy, grow, anything is possible! If you enjoyed this game, see our list of games similar to Lifecraft.

83%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:optimization, story

83% User Score Based on 334 reviews

Evospace is sandbox game with fully dynamic, procedurally generated world. Game about digging, exploring, building and technologies. If you enjoyed this game, see our list of games similar to Evospace.

95%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:optimization, grinding

96% User Score Based on 3,648 reviews

Critic Score 90%Based on 1 reviews

Take on the role of a Reactor Engineer working for SpaceChem, the leading chemical synthesizer for frontier colonies. Construct elaborate factories to transform raw materials into valuable chemical products! Streamline your designs to meet production quotas and survive encounters with the sinister threats that plague SpaceChem. If you enjoyed this game, see our list of games similar to SpaceChem.

48%Game Brain Score

Most mentioned negative aspects:music, graphics

72% User Score Based on 18 reviews

Discover molecules and learn about science in this addictive Sokoban-style puzzle game! If you enjoyed this game, see our list of games similar to Molecule: A Chemical Challenge.

Interactive Chemistry Simulations - Complete Collection Explore the fascinating world of chemistry with TWO comprehensive interactive simulations! Perfect for Key Stage 3 & GCSE students, these engaging educational tools bring chemical reactions to life right in your browser. Chemical Reactions Simulation Master over 20+ different chemical reactions with stunning molecular visualizations… If you enjoyed this game, see our list of games similar to Classroom Resource: Key Stage 3 Chemical reactions.

Interactive Chemistry Simulations - Complete Collection Explore the fascinating world of chemistry with TWO comprehensive interactive simulations! Perfect for Key Stage 3 & GCSE students, these engaging educational tools bring chemical reactions to life right in your browser. Chemical Reactions Simulation Master over 20+ different chemical reactions with stunning molecular visualizations… If you enjoyed this game, see our list of games similar to Classroom Resource: Chemical reactions.

92%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:optimization, grinding

92% User Score Based on 2,288 reviews

Terraform a lifeless rock into a lush and habitable world. Build trucks, trains, and sprawling factories on an enormous hexagonal planet. Grow its population to millions. Enjoy a dynamic simulation of atmosphere, temperature, water, and forests. If you enjoyed this game, see our list of games similar to Plan B: Terraform.

78%Game Brain Score

Most mentioned positive aspects:music, replayability

Most mentioned negative aspects:gameplay, graphics

78% User Score Based on 103 reviews

​UNLEASH DESTRUCTION ON AN EPIC SCALE Our unique technology simulates over 80,000* humans simultaneously on screen as you deploy devastating plagues, natural catastrophes, global conflicts and more tragedies. Designed using real-world data for an authentic simulation of humanity’s downfall. MORE THAN JUST A 2D SIMULATION  Watch disasters unfold in real-time, dynamically evolving and spreading b… If you enjoyed this game, see our list of games similar to Extinction Day.

93%Game Brain Score

Most mentioned positive aspects:gameplay, replayability

Most mentioned negative aspects:atmosphere, graphics

93% User Score Based on 477 reviews

From an uninhabited planet in space to an ecosystem full of life. In Planetary Life you will be able to shape a planet in the purest Sandbox Simulation style, playing with its mountains, seas and even its climate, to create the perfect habitat to harbor life. PLANETS Control a planet with the multiple tools available. Let the tectonic plates shape the mountains and seas, modify the climate, the… If you enjoyed this game, see our list of games similar to Planetary Life.

93%Game Brain Score

Most mentioned positive aspects:music, humor

Most mentioned negative aspects:gameplay, graphics

93% User Score Based on 278 reviews

Build. Program. Simulate. Logic World teaches you how circuits do math. If you enjoyed this game, see our list of games similar to Logic World.

91%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:optimization, story

91% User Score Based on 1,172 reviews

Thrive is a free, open-source game about the evolution of life. From the lowly tidepools of your home planet, you will rise to cosmic dominance. At every step, powerful creation tools and deep simulation mechanics will aid your species' development. If you enjoyed this game, see our list of games similar to Thrive.

63%Game Brain Score

Most mentioned positive aspects:graphics

Most mentioned negative aspects:gameplay

94% User Score Based on 18 reviews

Publication: Development of a virtual reality platform for effective communication of structural data in drug discoveryWe are excited to announce that we have been collaborating with The Genomics Institute of the Novartis Research Foundation (GNF) and have co-authored a paper that is being published in the Journal of Molecular Graphics and Modelling. The paper, titled “Development of a virtual rea… If you enjoyed this game, see our list of games similar to Nanome.

81%Game Brain Score

Most mentioned positive aspects:music, gameplay

Most mentioned negative aspects:replayability, story

86% User Score Based on 407 reviews

Critic Score 70%Based on 4 reviews

Splice is a puzzler where you are microbes that you "splice" to create a specific strand structure in a few amount of moves. If you enjoyed this game, see our list of games similar to Splice.

58%Game Brain Score

Most mentioned positive aspects:story, graphics

Most mentioned negative aspects:gameplay, monetization

73% User Score Based on 30 reviews

What is included in the prologue? Space Mechanic Simulator: Prologue is a kind of introduction to the world of space mechanics, where you will master the basics of your profession. You'll learn how to make quick decisions, manage resources, and use high-tech tools provided by AstrOpticon Corporation to help locate and fix almost any malfunction.About the Game Space Mechanic Simulator: Prologue is … If you enjoyed this game, see our list of games similar to Space Mechanic Simulator: Prologue.

51%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, music

51% User Score Based on 289 reviews

Smart Factory Tycoon is a factory management and automatization simulator game about running your dream factory with robots. Design your dream factory, plan all steps of production, research new technologies and become a tycoon! If you enjoyed this game, see our list of games similar to Smart Factory Tycoon.

95%Game Brain Score

Most mentioned positive aspects:story, music

Most mentioned negative aspects:grinding, stability

95% User Score Based on 2,910 reviews

In this challenging puzzle game, you build a computer from scratch and program it. It is a journey through the layers of abstractions of the computer. The game begins when you are abducted by aliens who are testing your intelligence, and from here a lighthearted sci-fi plot evolves. If you enjoyed this game, see our list of games similar to Turing Complete.

87%Game Brain Score

Most mentioned positive aspects:gameplay

Most mentioned negative aspects:graphics, music

100% User Score Based on 38 reviews

The most unforgiving little puzzler you will ever play, PyroMind is a simultaneously turn-based and real-time game full of bombs, explosions, and narrow escapes! Play alone, blow up your friend or challenge a bot in a unique dimension, where everything explodes and one small mistake can blast you to smithereens. Features Mercilessly explosive gameplay that simultaneously combines turned-based puzz… If you enjoyed this game, see our list of games similar to PyroMind.

89%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, story

94% User Score Based on 494 reviews

Critic Score 78%Based on 3 reviews

Sokobond is an elegantly designed puzzle game about chemistry. It's logical, minimalist, and crafted with love and science. If you enjoyed this game, see our list of games similar to Sokobond.

THE PERIODIC TABLE IS YOUR SANDBOX Alembic is a falling-sand laboratory built on the real periodic table. Pour elements together. Heat them, cool them, dissolve them, electrify them, compress them, irradiate them and see what happens. Reactions emerge from physical and chemical properties rather than fixed crafting recipes — and now you can build machines around those reactions, route matter th… If you enjoyed this game, see our list of games similar to Alembic.

About This project is an immersive virtual reality application that teaches the concept of cloning and growing micro potato tubers using hydroponics. The simulation is aimed at learners who want to acquire basic knowledge of modern agricultural technologies Game Description The project aims to make complex agricultural technologies, in particular hydroponics, accessible to a broad target grou… If you enjoyed this game, see our list of games similar to PlantClone VR.

   In this game you bring to life a newly hired government intern in the field of intellectual property, where your role is to analyze requests from people or companies to register their intellectual property, approving or denying these requests.     Based on this presentation, we created an innovative and educational game that is intended to be used as an educational tool for students, entreprene… If you enjoyed this game, see our list of games similar to IP Intern.

In “Chemist Wanted”, crafting isn't just about gathering a few ingredients and clicking “craft”. To create a compound, you need to combine different materials and processes to produce the desired result. This may involve reacting, dissolving, precipitating, extracting, evaporating, filtering, or even all of them. You will need to do many experiments and build your knowledge to find the best combin… If you enjoyed this game, see our list of games similar to Chemist Wanted.

41%Game Brain Score

Most mentioned negative aspects:music, graphics

41% User Score Based on 7 reviews

A puzzle game about living structures that evolve every time you move. If you enjoyed this game, see our list of games similar to Changes.

Realindustry is a hyper-realistic industrial automation simulator that blends deep strategy with authentic scientific principles, challenging players to build and optimize complex production chains using 231 real-world materials and 352 precise chemical recipes. Developed by AssemblyPrime, the game features a unique "mystery" theme where your industrial expansion is monitored by an unknown entity,… If you enjoyed this game, see our list of games similar to Realindustry.

62%Game Brain Score

Most mentioned positive aspects:gameplay, character development

Most mentioned negative aspects:story

100% User Score Based on 13 reviews

The Devil Card is a solo versus card battle game played on a 3×3 grid, inspired by Final Fantasy VIII’s Triple Triad. How to PlayEach match begins with you selecting five cards from your collection. Each card has four numeric values, one on each side, which determine its strength against adjacent cards. You take turns placing cards on the 3×3 Grid. When a card is placed next to an opponent’s… If you enjoyed this game, see our list of games similar to The Devil Card.

⭐ FidiMag Learning Suite An Interactive Journey Into Magnetisation Dynamics Spin Precession Playground (toy LLG visualization + damping control) Written by ChatGPT for Smazogz of Smazlabz – Dec 2025 What Is This App? The FidiMag Learning Suite is an interactive HTML5 experience that turns the complex world of micromagnetics into an accessible, colourful, and surprisingly fun set of simula… If you enjoyed this game, see our list of games similar to Dr. Fizzix - FidiMag Learning Suite.

88%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:grinding, stability

88% User Score Based on 778 reviews

In Solar Expanse, you take the lead of one of the early XXI century space exploration companies. Your goal will be to reach the planets, moons and asteroids of the system in order to mine and colonize them. Optimize the costs and schedule of the flights. Mind that each object is in constant motion, so exact planning is crucial. Utilize the gravity effects and slingshot your rockets further b… If you enjoyed this game, see our list of games similar to Solar Expanse - Space Exploration Manager.

An infection has struck the body! As the mighty T-Cell, it's your duty to eradicate the invading pathogens! Consume pathogens to earn mito energy, and use it to purchase upgrades and summon allies in your battle to protect the body. If all your body cells die, it's game over for you. Utilising squishy softbody physics and hand-drawn graphics, this game will take you on a journey through the body… If you enjoyed this game, see our list of games similar to Going Viral.

55%Game Brain Score

Most mentioned positive aspects:music

Most mentioned negative aspects:gameplay, graphics

91% User Score Based on 11 reviews

JOIN US ON DISCORD! About the Game Get ready to enter a network of futuristic puzzles where every room challenges your intellect. In Cube Mind, every element in the environment is more than just decoration — it’s a strategic tool you must learn to master. Activators Trigger mechanisms, open doors, and reshape the level by placing cubes with precision. These smart switches react to your actio… If you enjoyed this game, see our list of games similar to Cube Mind.

53%Game Brain Score

Most mentioned positive aspects:graphics

Most mentioned negative aspects:gameplay

90% User Score Based on 10 reviews

DIE, REDROP, REPEAT. In this Platformer, every Death leaves a platform behind; Climb your mistakes! RAGE, CRY, ADAPT. Then do it all again. Try now and prove you're only *mostly* bad. If you enjoyed this game, see our list of games similar to ReDrop.

91%Game Brain Score

Most mentioned positive aspects:gameplay, replayability

Most mentioned negative aspects:graphics, music

91% User Score Based on 365 reviews

Bioprototype, a Roguelike & Skill Customizing Rhapsody! This is an auto-bomber with programming elements. Customize your character skills with visual programming, utilize enemy organs to finish the mutation, and construct the ultimate prototype, one can survive in the endless wave of flesh. • Set your own skill trigger logics • More builds: Bullet Master, Flesh Army, Virus Master, and more • 24 u… If you enjoyed this game, see our list of games similar to Bioprototype.

22%Game Brain Score

Most mentioned positive aspects:gameplay, emotional

Most mentioned negative aspects:story, stability

36% User Score Based on 11 reviews

Oil Refinery - The Simulation puts you in charge of a fully operational oil refinery, where precision, efficiency, and strategic decision-making determine success. From crude oil intake to the production of refined fuels and valuable chemicals, every step of the refining process is in your hands. Master the Refining Process – Control distillation, cracking, and blending operations to produce gas… If you enjoyed this game, see our list of games similar to Oil Refinery - The Simulation.

72%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:optimization

100% User Score Based on 23 reviews

Hex Blast is a horde survival x roguelike deckbuilder where you strategize on a hex grid, chaining explosive card combos to wipe out cyber hordes. Build your deck, collect overclocked chips, and discover the most broken builds to annihilate cyber threats—before they overwhelm you. If you enjoyed this game, see our list of games similar to Hex Blast.

84%Game Brain Score

Most mentioned positive aspects:story, optimization

Most mentioned negative aspects:grinding, replayability

92% User Score Based on 2,366 reviews

Critic Score 74%Based on 7 reviews

Program little workers to solve puzzles. The machines are coming...for your job. If you enjoyed this game, see our list of games similar to Human Resource Machine.

Spark is an adventure-puzzle game that encourages selflessness and provokes thoughtful problem solving. You are Spark, an animated and bright bundle of energy. Through exploring an electronic maze in the depths of a computer, you come to understand your purpose in life of bringing connection, vitality, and exuberance to those around you. By connecting components, solving puzzles, and powering y… If you enjoyed this game, see our list of games similar to Spark.

79%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, grinding

79% User Score Based on 386 reviews

You land on a frozen planet with an important mission: to make it habitable. To do that, you’d need to harvest resources, craft tools, burn fires, melt the ice, plant trees and produce oxygen. Estimated time for the task: over 9000 years.Or you can make robots to do that for you!Enter CraftoMate! They can be scripted with visual programming to perform all kinds of tasks. More importantly, they can… If you enjoyed this game, see our list of games similar to Craftomation 101: Programming & Craft.

95%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

95% User Score Based on 336 reviews

The engineering roguelike. Construct your own skills by wiring up modules. Build crazy machines to zap the monsters and trigger satisfying chain reactions. If you enjoyed this game, see our list of games similar to Rogue Voltage.

84%Game Brain Score

Most mentioned positive aspects:gameplay, music

87% User Score Based on 78 reviews

Critic Score 70%Based on 1 reviews

A beautifully minimalist puzzle game combining chemical bonds and puzzling pathfinding. If you enjoyed this game, see our list of games similar to Sokobond Express.

67%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:story

95% User Score Based on 21 reviews

Ever had something turn out so disastrously that you wished you could just reset and start all over again? In this game you may just have the chance to reboot the grandest experiment ever gone wrong. That experiment? The Universe itself. You will find yourself inside an amazing single mechanism, impressive in its scale. Taking control of its lonely resident - Artificial Intelligence named HAWKING,… If you enjoyed this game, see our list of games similar to Total Reload.

97%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:grinding, stability

97% User Score Based on 773 reviews

Mudborne is a laid-back nature sim game about breeding & collecting frogs! Visited in your dreams by a mysterious deity, you begin a journey to help rediscover Her lost children. If you enjoyed this game, see our list of games similar to Mudborne.

95%Game Brain Score

Most mentioned positive aspects:music

Most mentioned negative aspects:graphics, optimization

95% User Score Based on 191 reviews

SoundStage is a virtual reality music sandbox built specifically for room-scale VR. Whether you’re a professional DJ creating a new sound, or a hobbyist who wants to rock out on virtual drums, SoundStage gives you a diverse toolset to express yourself. If you enjoyed this game, see our list of games similar to SoundStage.

78%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:grinding, optimization

76% User Score Based on 3,372 reviews

Critic Score 81%Based on 11 reviews

Per Aspera is a narrative-driven strategy game with the goal of overcoming the challenge of terraforming Mars. Explore the planet, gather resources, and make strategic decisions as you live the fantasy of scientifically-based interplanetary expansion. Hardship awaits. If you enjoyed this game, see our list of games similar to Per Aspera.

73%Game Brain Score

Most mentioned positive aspects:music, graphics

Most mentioned negative aspects:stability, gameplay

73% User Score Based on 82 reviews

It's your chance of becoming the master of your tea estate, to brew your journey towards discovering ancient secrets, nurturing the plant with skills beyond perfection, and finding your way through processing to be called the Ultimate Tea Master. If you enjoyed this game, see our list of games similar to Tea Garden Simulator.

57%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

57% User Score Based on 825 reviews

Project Aura is a simulation/strategy videogame where you take control of a colony of climate disaster survivors. In the near future, humans will face the drastic consequences of climate change. Forced to take refuge in vital reserves using cryo-preservation, they await a second chance. At the end of the 21st century, humans, finally aware of the great climate disaster, dedicated their efforts n… If you enjoyed this game, see our list of games similar to Project AURA.

87%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:grinding, stability

87% User Score Based on 284 reviews

MHRD is a hardware design game, in which you design various hardware circuits in a hardware description language. The hardware circuits you design get more complex as you go until you create a fully functional CPU design. If you enjoyed this game, see our list of games similar to MHRD.

63%Game Brain Score

Most mentioned positive aspects:humor, story

Most mentioned negative aspects:gameplay, music

100% User Score Based on 14 reviews

Created by a physics teacher, SPACE TOW TRUCK is a REAL physics puzzle game that Isaac Newton would have loved! With this recreational-educational game, you'll solve puzzles and master physics while discovering the Moon! "I’ve come away from my great time with Space Tow Truck a little smarter, a little more knowledgeable of some basic mechanics of physics and in the history of science in general.… If you enjoyed this game, see our list of games similar to SPACE TOW TRUCK - Isaac Newton's Favorite Puzzle game.

96%Game Brain Score

Most mentioned positive aspects:gameplay, stability

Most mentioned negative aspects:grinding, graphics

96% User Score Based on 287 reviews

Minesweeper, but you only solve each situation once. If you enjoyed this game, see our list of games similar to Bombe.

85%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, story

85% User Score Based on 86 reviews

1 puzzle, 4 views. Grab your test tubes and enter the lab to solve a unique puzzle game based on chemical compounds. Match the chemical elements to achieve more than 900 different compounds and see how far you can go. Do you have what it takes? If you enjoyed this game, see our list of games similar to Breaking Good.