Games like Powerhouse of The Immune System

51%Game Brain Score

Most mentioned positive aspects:graphics, humor

Most mentioned negative aspects:gameplay, music

56% User Score Based on 43 reviews

Prophour23 is a fast-paced, replayable real-time strategy. It's designed for short, quick plays. A single playthrough will take you about 15 minutes, if you're good. But the next one will be different. And another one as well. If you enjoyed this game, see our list of games similar to Prophour23.

55%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

55% User Score Based on 102 reviews

Take control of a determined White Blood Cell on a quest for self discovery, vengeance, punishment and annihilation of all evil germs who would dare infiltrate an unsuspecting and innocent human body in this unique and organic experience. Battle evil germs by slamming into them, using your Powerbutt ability to further enhance the damage and pain inflicted. If you enjoyed this game, see our list of games similar to Germ Wars.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

The Crafter’s Defense is an action-defense game, combining elements of both tower defense and action games. The player takes on the role of a dungeon core, a human reincarnated as a sentient dungeon, and must defend against waves of invaders. In place of towers, players place traps and dungeon monsters which can be placed directly on the invasion path, where they can attack the invaders, as well a… If you enjoyed this game, see our list of games similar to The Crafter's Defense.

If the game has piqued your interest, please don't hesitate to try the demo. You can also access the demo on Steam. You can take a look at our game's Steam page below and make me very happy by adding FarmTech to your WISHLIST. Thank you for your support Steam  https://store.steampowered.com/app/2361500/FarmTech/ FARMTECH In this world taken over by aliens, you have been given a special mis… If you enjoyed this game, see our list of games similar to FarmTech.

Defend the body in vaXinator, a fast-paced action roguelike! As the last white blood cell, unleash powerful abilities and antibodies to fight off waves of infections. Test your reflexes in this microscopic battle for survival. How long can you hold the line? If you enjoyed this game, see our list of games similar to vaXinator.

Metacell: Genesis ARCADE is an arcade game inspired by old-school arcade games, with the match 3 mechanic. The basic gist of Arcade mode is a score attack mechanic where you want to survive to level 100 with the highest score. Fight back a never ending spawn of game pieces by making matches of 3 or more before the board fills up, or even worse, you are killed by one of the traps that could spawn a… If you enjoyed this game, see our list of games similar to Metacell: Genesis ARCADE.

What The Fortress!? is surprisingly a tower defense game, but with some twists! You can modify the layout of the map, plan the paths of the incoming enemies, and research dozens of upgrades and towers.Be a real road architectYou have complete control over the map. Carve the path of your enemies, set deadly traps like Ice, Water or Magma tiles. You won't only build towers, but construct the ways be… If you enjoyed this game, see our list of games similar to What The Fortress!?.

Stranded in another solar system on a confusing planet, you must source fuel for your ship. You'll learn how to research, build and defend in increasingly hostile scenarios across the planet. Hive tasks you with mastering three components of colonisation: - Agriculture: providing food to your structures to boost their productivity, - Industry: mining resources and refining them, - Defence: preve… If you enjoyed this game, see our list of games similar to Hive.

70%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, optimization

70% User Score Based on 281 reviews

Survival Machine is a 4 player co-op, 3rd person, survival-adventure game set in vibrant, diverse landscapes. Navigate the ever-changing world aboard the colossal Machine that doubles as your fortress, homestead, and transport. Whether braving the game solo or with friends, explore biomes full of random challenges to gather resources, craft new upgrades, and build structures that will help you sur… If you enjoyed this game, see our list of games similar to Survival Machine.

96%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:replayability, stability

96% User Score Based on 108 reviews

Space Raiders in Space is a wave defense roguelike mixing squad management and tower defence mechanics. Command your almost competent crew to loot weapons and supplies, build defenses, and fight their way through the Bugpocalypse. If you enjoyed this game, see our list of games similar to Space Raiders in Space.

94%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, monetization

97% User Score Based on 15,544 reviews

Critic Score 90%Based on 5 reviews

A minimalist game about building and defending a little kingdom. Thronefall is a classic strategy game without unnecessary complexity, just some healthy hack-and-slay. Build up your base during the day, and defend it ‘til your last breath at night. If you enjoyed this game, see our list of games similar to Thronefall.

75%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, music

75% User Score Based on 478 reviews

Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy. If you enjoyed this game, see our list of games similar to Defend Your Life: TD.

80%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

88% User Score Based on 9,193 reviews

Critic Score 60%Based on 3 reviews

Kingdom is a 2D side-scrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic. If you enjoyed this game, see our list of games similar to Kingdom: Classic.

86%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:stability, grinding

91% User Score Based on 7,467 reviews

Critic Score 81%Based on 11 reviews

BUILD, EXPLORE, DEFEND, CONQUER If you enjoyed this game, see our list of games similar to Kingdom: Classic.

97%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, music

97% User Score Based on 226 reviews

Check out the updated version on Steam here! The world is under siege from an unknown enemy. Gates are appearing, spawning demonic entities. Major cities have been destroyed with overwhelming force. Most of the population has been decimated, but the dead rise again to feast on the living. There was no warning, no signs, no dark omen... Just death and destruction. This is the apocalypse. There are… If you enjoyed this game, see our list of games similar to Endgame: Road To Salvation.

Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

Survive the swarm. Lure drones into traps, upgrade your defenses, and hold out as long as you can. Just skill, strategy, and chaos as the horde grows deadlier every minute. Never stop. Buffs grant hope, debuffs take it away. How long can you survive? Features: Kite swarms Bait enemies into traps Upgrade your skills Find Repair Kits and Upgrade your defenses Explore to locate unique one time usable… If you enjoyed this game, see our list of games similar to Swarm Me.

69%Game Brain Score

Most mentioned positive aspects:gameplay, music

100% User Score Based on 20 reviews

Can you build and fight through endless levels to bring life and color to your world? Customize towers and troops to ward off enemies in this fast-paced and colorful tower defense. If you enjoyed this game, see our list of games similar to HexeD.

The Road to Gelendzhik Palace - don't let your enemies enter the domain! If you enjoyed this game, see our list of games similar to The Road to Gelendzhik Palace.

52%Game Brain Score

Most mentioned positive aspects:music, optimization

Most mentioned negative aspects:gameplay, replayability

71% User Score Based on 24 reviews

Build, manage and defend your fantasy tavern. If you enjoyed this game, see our list of games similar to TavernHold.

An infection has struck the body! As the mighty T-Cell, it's your duty to eradicate the invading pathogens! Consume pathogens to earn mito energy, and use it to purchase upgrades and summon allies in your battle to protect the body. If all your body cells die, it's game over for you. Utilising squishy softbody physics and hand-drawn graphics, this game will take you on a journey through the body… If you enjoyed this game, see our list of games similar to Going Viral.

58%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, replayability

82% User Score Based on 22 reviews

MAKE YOUR ESCAPEPlay as an ancient Chimera locked within a subterranean tower in this rogue-lite dungeon crawler. Battle through floors of powerful creatures on your ascent from the ancient prison. GRAFT YOUR WAY TO POWERTake the powers from your enemies by grafting their limbs to use unique abilities. Use trinkets to create a variety of builds and become an unstoppable force. Unlock relics from … If you enjoyed this game, see our list of games similar to Chimera.

91%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:optimization, story

91% User Score Based on 1,172 reviews

Thrive is a free, open-source game about the evolution of life. From the lowly tidepools of your home planet, you will rise to cosmic dominance. At every step, powerful creation tools and deep simulation mechanics will aid your species' development. If you enjoyed this game, see our list of games similar to Thrive.

71%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:stability, story

71% User Score Based on 410 reviews

This Goblin Tribe Simulator brings a challenging blend of chaos and creativity to the city-building genre. Build dwellings, manage your resources, defend your goblins, and grow your tribe to face other races and even the Gods! Do you have what it takes to control the chaos and rule the unruly? If you enjoyed this game, see our list of games similar to Goblins of Elderstone.

62%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:grinding, story

62% User Score Based on 198 reviews

The horde is here to eat your brain and murder every single one of your scientists. Gather your forces, this is the last stand before we lose the facility! Place guards, close doors, and position traps. Survive as long as you can! Endless Horde is a Tower Defense game where the enemies spawn in different areas every time you play, don’t get too comfortable with a strategy or they will overrun you … If you enjoyed this game, see our list of games similar to Endless Horde.

61%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, optimization

61% User Score Based on 190 reviews

‘Alien Marauder’ is a real-time strategy game with survival and confrontation theme.In this game, you will be the leader to a treacherous alien planet, get all kinds of supplies to build your outpost, and deploy troops to resist the incoming vexans strategically! If you enjoyed this game, see our list of games similar to Alien Marauder.

83%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, stability

86% User Score Based on 7,734 reviews

Critic Score 78%Based on 5 reviews

Mystery to discover, darkness to conquer. A noio and Raw Fury game. If you enjoyed this game, see our list of games similar to Kingdom: New Lands.

Escape From The Red Planet is a tower defence game that puts you in the shoes of Commander Abigail Blackwell of The Orion III. After a crash landing that left you stranded on Mars, you must employ serious resource management to keep yourself safe from incoming Martian attacks. While you wait for rescue, keep your solar batteries charged to build up your attack and defence. KEY FEATURES - Three di… If you enjoyed this game, see our list of games similar to Escape From The Red Planet.

80%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:replayability, grinding

80% User Score Based on 523 reviews

Join the wonderful and amazing world of microorganisms. If you enjoyed this game, see our list of games similar to Microcosmum: survival of cells.

73%Game Brain Score

Most mentioned positive aspects:graphics, music

Most mentioned negative aspects:gameplay

73% User Score Based on 51 reviews

Plant your strategy! Defend mystical trees in this captivating strategy game If you enjoyed this game, see our list of games similar to Nanuleu.

69%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, stability

69% User Score Based on 127 reviews

An action-farming-roguelite, full of whimsical flora and mischievous creatures that really want to ruin your dark and mysterious plans of… Going vegan! If you enjoyed this game, see our list of games similar to Voltaire The Vegan Vampire.

59%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, grinding

53% User Score Based on 385 reviews

Critic Score 66%Based on 7 reviews

Machiavillain is an evil mansion management and strategy game, inspired by Dungeon Keeper, Prison Architect and all the horror movie clichés! Build your own manor, raise your monsters, set up your traps, and exterminate your victims. But to gain reputation you'll have to slay by the horror movie rules! If you enjoyed this game, see our list of games similar to MachiaVillain.

83%Game Brain Score

Most mentioned positive aspects:gameplay, optimization

Most mentioned negative aspects:graphics, stability

83% User Score Based on 263 reviews

Castle Craft is a game where players can build huge castles in an ancient wartorn world and must defend them against hordes of enemies in siege battles of epic proportions. Castle Craft is a unique blend of the voxel sandbox genre, action, and tower defense. If you enjoyed this game, see our list of games similar to Castle Craft.

63%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:grinding, stability

62% User Score Based on 3,739 reviews

Critic Score 70%Based on 1 reviews

Begin a journey in the beautiful world! Build your own town anywhere and explore the myterious lands anytime. Nothing is impossible in the open world: Be a legendary warrior and 5-star chef at the same time! If you enjoyed this game, see our list of games similar to Tree of Life.

63%Game Brain Score

Most mentioned positive aspects:graphics

Most mentioned negative aspects:gameplay, story

63% User Score Based on 98 reviews

Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. If you enjoyed this game, see our list of games similar to Infectious.

74%Game Brain Score

Most mentioned positive aspects:gameplay, atmosphere

Most mentioned negative aspects:story, graphics

74% User Score Based on 149 reviews

World War 2 - Bunker Simulator is a bunker life simulator with shooter elements. Player has to perform subsequent missions, takes care of his needs and with all his arms defends the bunker - even when he has no energy and runs out of ammunition. If you enjoyed this game, see our list of games similar to WW2: Bunker Simulator.

38%Game Brain Score

Most mentioned positive aspects:gameplay, optimization

Most mentioned negative aspects:stability, graphics

38% User Score Based on 85 reviews

Vendor Chronicles puts you in the shoes of a Vendor in post-apocalyptia! Manage your trade, set your defences, deal with locals and fight hordes of mutants in this new perspective on post-apocalyptic survival! If you enjoyed this game, see our list of games similar to Desolate Wastes: Vendor Chronicles.

73%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

73% User Score Based on 80 reviews

Hello GameJolt! A Little about us, Game Munchers is a small group of people with a passion for game development. We have made a few 2D MMORPG's for fun, but we really want to start our focus on... If you enjoyed this game, see our list of games similar to Monster Outbreak.

87%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, stability

87% User Score Based on 337 reviews

In Castle of Alchemists, a tower defense/top-down action hybrid game with amazing pixel art graphics, play as the Bellator, alchemically enhanced defender, to fight against invaders from other worlds. Delve into the castle, set your traps, equip powerful weapons and gears, and reclaim the castle piece by piece. If you enjoyed this game, see our list of games similar to Castle Of Alchemists.

84%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:story, monetization

85% User Score Based on 453 reviews

Critic Score 80%Based on 2 reviews

"Long ago a computer scientist called Dr Sepulveda created a beautiful digital world existing entirely within a computer network of his own invention. This world was called Darwinia and it was inhabited by a peaceful, law-abiding digital life-form called the Darwinians. If you enjoyed this game, see our list of games similar to Multiwinia.

53%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:stability, optimization

53% User Score Based on 5,053 reviews

An epic adventure awaits you in Castle Story, a strategy game where you command friendly creatures called Bricktrons. Have them explore, carve, dig and gather resources from vast, spectacular floating islands, reshaping the voxel-based world to your desire! Design and build any structure you can imagine! From mighty and legendary castles to sprawling Bricktron villages. Beware, your Bricktrons w… If you enjoyed this game, see our list of games similar to Castle Story.

79%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, stability

79% User Score Based on 926 reviews

Dwarfs!?' offers an addictive, fast paced arcade-like experience, with plenty of difficulties and game modes to play around in. As the new overseer for your underground Dwarf base, your job is to manage the small colony and make it as rich as possible, before they meet their inevitable doom! To survive as long as possible, you’ll have to steer and guide your greedy little fellows to the richest p… If you enjoyed this game, see our list of games similar to Dwarfs!?.

18%Game Brain Score

Most mentioned positive aspects:emotional

Most mentioned negative aspects:gameplay, story

30% User Score Based on 10 reviews

"Reverse tower defense" game, or maybe "snake with enemies". Lead small groups of creatures through guard towers defense.  Control using keyboards. This is a demo of Protolife: Other Side game released on Steam. This demo includes a tutorial and the first zone only. If you enjoyed this game, see our list of games similar to Protolife: Other Side.

59%Game Brain Score

Most mentioned positive aspects:gameplay, story

Most mentioned negative aspects:graphics

93% User Score Based on 14 reviews

Homeless Life Simulator throws you into the brutal reality of street life. You start with nothing, no home, no money, no safety, and must fight to survive each day. Hunger, debt, and danger are everywhere, but so are the chances to rise again. Every choice matters, and the streets will test your will to endure. From begging, recycling, and stealing to studying, working, and even taking risks in c… If you enjoyed this game, see our list of games similar to Homeless Life Simulator.

Not Ready for Service is a turn-based tactics game on a hex grid, with no initiative order. In 2239, you're an immunician piloting microbots inside a human body. Form a squad from dozens of units, fight pathogens, save lives, advance your career, and understand the difference between self and other. If you enjoyed this game, see our list of games similar to Not Ready for Service.

Pinevale Settlements is a colony-building simulation that combines production and defense cycles. Start with a small settlement; collect resources, build structures, automate production, develop technology, and keep your colony alive against increasingly powerful raids. The game has undergone major changes in design and gameplay after the big update. We have a long way to go and will continue to … If you enjoyed this game, see our list of games similar to Pinevale Settlements.

A century of damnation. One hundred days for salvation.  Age of Damnation is a top-view strategy set in a fantasy medieval world. By day, you explore the forest and build your settlement. By night, you defend against waves of monsters spawned by the damnation mist. Each level gives you 100 days to prepare for the final battle. Will you make it to the end, or will the curse claim you too? Main Ob… If you enjoyed this game, see our list of games similar to Age of Damnation.

Kings of Cratia offers an experience that mixes real-time strategy and first-person shooter mechanics. Build your new village and manage your resources efficiently. Watch out for changing weather conditions. Be ready to defend your villages every day when night falls! RTS or FPS, you are free to protect your village the way you want it. You can also command your troops in FPS mode. Every … If you enjoyed this game, see our list of games similar to Kings of Cratia.

58%Game Brain Score

Most mentioned positive aspects:gameplay, optimization

93% User Score Based on 14 reviews

Tower Knight is a deck-building & tower defense strategy game. Make different plans for each challenge's starting deck. Build your deck and adapt your strategy. The map grows as you play your cards. Victory and Defeat Win by surrounding all enemy towers with walls. Your knight can defend themselves, but has limited health. Deck-Building & Tower Defense Build you… If you enjoyed this game, see our list of games similar to Tower Knight.