Games like Immune Commander

# BIOFIGHTERS [Watch the BIOFIGHTERS Trailer on YouTube]( ) ## Overview **BIOFIGHTERS** is an action-packed educational game that immerses players in the world of the immune system. Players take control of different immune cells, each with unique roles, to defend the body against increasingly dangerous pathogens. The game is structured into two mini-games and one larger level, forming a co… If you enjoyed this game, see our list of games similar to BIOFIGHTERS.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

65%Game Brain Score

Most mentioned positive aspects:atmosphere, emotional

Most mentioned negative aspects:story, gameplay

88% User Score Based on 25 reviews

Space Tales is a sci-fi RTS where you build fortified bases, manage resources, and command retro-futuristic armies. Adapt to deadly alien factions, capture huge monsters and turn them into powerful allies as humanity fights to survive among the stars. If you enjoyed this game, see our list of games similar to Space Tales.

Welcome to Yu Roguelike A Game That Got a Little Out of Hand. This project started as a simple, turn-based roguelike. But over several years of solo development, it became... something else. It's my love letter to gaming, programming, and the sheer joy of creation, free from any commercial constraints. And now, it's yours to explore. It's a massive world bu… If you enjoyed this game, see our list of games similar to Yu Roguelike.

In 2091, the military AI Weave has taken the skies. Three pilots fight on three lanes at once — and back aboard the carrier, they share the hours away from the battlefield with you. Every word you say quietly changes where you stand with them. If you enjoyed this game, see our list of games similar to STEEL WING: WEAVEBREAKER.

"Throne of ages" blends roguelike progression with grand-scale RTS gameplay, letting players command multiple legions across vast battlefields. Command your troops in real-time across dynamically generated battlefields where every campaign offers unique randomized upgrades and unit evolution. If you enjoyed this game, see our list of games similar to Throne of Ages.

Immune Defense Control the body’s last line of defense in this microscopic tower defense game! About the Game Immune Defense is a colorful 2D tower defense game where you play as the body’s immune system, protecting it from waves of invading bacteria, viruses and parasites. You’ll place powerful immune cells like macrophages, neutrophils, and T-cells along the bloodstream to stop infections fr… If you enjoyed this game, see our list of games similar to ImmuneDefense.

Ready for some chaos? Command 5 characters in this Roguelite Tower Defense! Build your dream team, crush enemies, and have a blast with adorable pixel art! If you enjoyed this game, see our list of games similar to Mayhem Maidens.

The Bacterium is an Real-time strategy game created for the GMTK  2024  Game Jam. The theme :  Built to SCALE.This game uses scales in 2 distinct ways, first is the setting, since you are playing as the immune system, the scale is microscopic. there is also a gameplay element to scale, the bacteria will increase in size the longer its alive. size is proportional to the bacterium's health. BUGS: W… If you enjoyed this game, see our list of games similar to The Bacterium.

Just as the COVID-19 pandemic is starting to sweep through the world, Antidote Laboratories receives a strange package. You are assigned to study it and WHAM!, get thrown into the frontlines of medical science. Based on real events and loaded with useful facts about COVID-19, the Antidote COVID-19 takes you on a science adventure! • Defend the stem cell against viruses and bacteria • Build your o… If you enjoyed this game, see our list of games similar to Antidote COVID-19.

45%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:optimization

67% User Score Based on 18 reviews

The most relaxing, difficult, & satisfying game. Poker TD is a hypnotically satisfying card game with tons of replay value. Every game you play is much different then the last. Create broken combinations and see if you have what it takes to win a game of Poker TD. If you enjoyed this game, see our list of games similar to Poker TD.

Shadow Dungeon is a dark fantasy action RPG featuring a retro-inspired visual style reminiscent of late 1990s role-playing games. Choose your hero and embark on an epic journey through a vast and mysterious world. From eerie and terrifying dungeons to solemn ancient temples, from scorching deserts to haunted ruins filled with restless spirits, and even to places no mortal has ever set foot in — in… If you enjoyed this game, see our list of games similar to Shadow Dungeon.

Chains of Acquisition is a multiplayer turn-based economy simulator where you strategically manage your corporate empire, grounded in real-world economic principles. Expand your supply chain, manipulate shares, master industries, patent products, and more to dominate the competition. If you enjoyed this game, see our list of games similar to Chains of Acquisition.

BIOLOGY IS THE ULTIMATE SANDBOXWelcome to the Vanguard Initiative. STEMMIES™ is not just a medical simulator; it is a living, breathing kinematic ecosystem that exists directly on your screen. Powered by the proprietary TitanEngine™, you are tasked with managing a complex biological metropolis, tracking pathogen vectors, and building an unstoppable medical empire. Bio-Economic Domination: Tr… If you enjoyed this game, see our list of games similar to Stemmies.

RENDHELM — THE DRAGONSEAAn age ago the World-Wyrm fell from the heavens and struck the center of the world. Its body became the land. Its blood — the Ichor— became all magic. And the vast inland sea that filled the crater still holds the perfect shape of a dragon reared and rampant: jaws flung wide toward the west, tail curling over the northern waters, claws reaching into the south. No cartograph… If you enjoyed this game, see our list of games similar to Rendhelm: World of the Dragonsea.

It’s a card game where you build a deck, draw cards, and strategically place towers on a tile grid to earn gold. And you must defend your empire from the enemies closing in. They won’t let you build in peace. Play time per run: 20~40 min All stages cleared: 6+ hours + Endless mode If you enjoyed this game, see our list of games similar to Card Colony.

91%Game Brain Score

Most mentioned positive aspects:gameplay, replayability

Most mentioned negative aspects:optimization, graphics

91% User Score Based on 56 reviews

Golemworks is an experimental, strategic fusion of roguelike and factory builder. You must assemble a factory that generates an army of automatons. These automatons automatically fight and defend your golem foundry from waves of encroaching shadows. Molds activate on a cooldown, and generate a golem core - the 'recipe' for an automaton. Catalysts are the production infrastructure. They… If you enjoyed this game, see our list of games similar to Golemworks.

55%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:optimization, graphics

80% User Score Based on 20 reviews

Coreless is a single-player action roguelite built around active combat, layered builds, and risk-reward decisions. During each run, your build takes shape through Powers, Boosters, Chest Items, Challenge Rewards, Special Missions, and Equipment. These choices affect how you move, when you engage, how you handle pressure, and which rewards are worth pursuing. Risk and Treasure Find sit at the … If you enjoyed this game, see our list of games similar to Coreless: Prologue.

Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

88%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

88% User Score Based on 120 reviews

A challenging survival RTS roguelite about surviving against thousands of enemies. Start each run with the hopes of going as deep as you can. Customize your army with different weapons, armour and upgrades. When you inevitably fail, use the knowledge gained to make your next attempts stronger through meta progression upgrades. Hold your ground Once you start fueling your drill, a massive swarm… If you enjoyed this game, see our list of games similar to Deep Among the Swarm.

71%Game Brain Score

Most mentioned positive aspects:humor

Most mentioned negative aspects:gameplay, graphics

83% User Score Based on 36 reviews

Last Outpost is a minimalist Base Building & Strategy game where you build and defend your outpost in zombie apocalypse. Choose your vehicle and loadout before embarking on your adventure. Use your abilities and control your units to eliminate all threats. Will you manage to defend your outpost? If you enjoyed this game, see our list of games similar to Last Outpost.

86%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, grinding

86% User Score Based on 404 reviews

Roman Triumph is a survival city-builder / colony-sim set in Roman times where you must lead your people, build a city from the ground up and fortify it with walls, ballistae, archer towers and other Roman defenses to survive against the hordes of Barbarians, ferocious Hydra, Minotaur, Cerberus, and other mythological beasts. Creating an Empire In order for your city to thrive, you must keep your … If you enjoyed this game, see our list of games similar to Roman Triumph: Survival City Builder.

49%Game Brain Score

Most mentioned positive aspects:gameplay, story

Most mentioned negative aspects:grinding, music

48% User Score Based on 336 reviews

Critic Score 50%Based on 2 reviews

Oil Rush is a naval strategy game that takes place in a world where nuclear war has melted the ice caps, changing the face of the planet forever. Oil Rush offers unique gameplay, avoiding micromanagement of every single unit, while still providing full control over all important aspects of strategy and economy. If you enjoyed this game, see our list of games similar to Oil Rush.

86%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, replayability

86% User Score Based on 109 reviews

Defend your Chrysalis from growing hordes of monsters in this hybrid game that combines elements of tower defense, survival, and roguelike RPGs. Explore procedurally generated levels, possess and control animals, and grow deadly gardens. How far can you get before the next wave of monsters attacks? In Chrysalis, you play the role of an incorporeal Wisp tasked with defending a magical Chrysalis fr… If you enjoyed this game, see our list of games similar to Chrysalis.

96%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:story, stability

96% User Score Based on 230 reviews

CleanFall is a sandbox survival roguelike that combines ship-building, tower defense, and a unique alchemic turret system. You must leverage whatever you can find to survive in this dynamic underground world! 1.0 ROADMAPNote: additional content may be added based on community feedback. FEATURES Dynamic Ecosystem – Enter a ravenous ecosystem teeming with exotic creatures, and learn to exploit the… If you enjoyed this game, see our list of games similar to CleanFall.

79%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

81% User Score Based on 169 reviews

Critic Score 73%Based on 3 reviews

A dieselpunk real-time tactics roguelite set in an alt-history World War 2. Grit and Valor – 1949 puts you in command of an elite Mech Squadron. Think fast and battle the Evil Axis forces to liberate Europe. Upgrade your Mechs and Pilots and develop new strategies to neutralise the enemy HQ! If you enjoyed this game, see our list of games similar to Grit and Valor - 1949.

77%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:grinding, stability

93% User Score Based on 2,799 reviews

The Cataclismo left us broken. Construct fortresses and defend against waves of Horrors in this mix of tower defense and real-time strategy. Lead an expedition beyond the gates of the last city, and reclaim mist-shrouded ruins as you rebuild humanity—stone by stone. If you enjoyed this game, see our list of games similar to Cataclismo.

53%Game Brain Score

Most mentioned positive aspects:graphics, atmosphere

Most mentioned negative aspects:gameplay, story

53% User Score Based on 118 reviews

In Pandemic Train you are in charge of the crew aboard a train roaming the postapocalyptic wasteland, ravaged by both war and a deadly plague. Your goal is to survive long enough to discover the cure… or die trying. Humanity’s fate is in your hands! Start your journey now! If you enjoyed this game, see our list of games similar to Pandemic Train.

87%Game Brain Score

Most mentioned positive aspects:music, gameplay

Most mentioned negative aspects:story, optimization

87% User Score Based on 76 reviews

Acid Planet is a Tower-Defense game with elements of Horde-Survival, Action Roguelike, and RTS. It's a game for people who like building, strategy, tactics and epic automated sci-fi battles. Drop to the surface, lure in the horde and bag the biggest kaiju you can handle. BUILD YOUR BASEConstruct towers and drone factories to defend your ship from the horde. Make use of the environment - strategic … If you enjoyed this game, see our list of games similar to Acid Planet.

69%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:replayability

92% User Score Based on 26 reviews

Explore. Mine. Build. Fight. Destroy The Monoliths is a single-player real-time mining tower offense roguelike where you explore a randomly generated map, mine the terrain to get resources, and build turrets to both protect your base and fight monoliths that keep spawning ever more minions. If you enjoyed this game, see our list of games similar to Destroy The Monoliths.

88%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, story

88% User Score Based on 586 reviews

Tower Factory is a game where you have to build a factory that allows you to create enough towers to defend yourself from enemies. You'll need to find and destroy the enemy castle before it becomes too powerful and its monsters overwhelm you! Features: Constantly build, expand, and upgrade your factory. Acquire resources to build more and better towers. Explore the map to locate the enemy castle, … If you enjoyed this game, see our list of games similar to Tower Factory.

95%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:music, stability

95% User Score Based on 1,207 reviews

WHAT IS INCLUDED IN THE PROLOGUE?The Riftbreaker Prologue allows you to experience the events taking place before the story campaign of the main game. Explore an entirely new world. Gather resources. Build up a base. Defend yourself from thousands of alien creatures. Or just take the scenic route and do whatever you want - the choice is yours.STORYYou play the role of captain Ashley S. Nowak - you… If you enjoyed this game, see our list of games similar to The Riftbreaker: Prologue.

76%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story

76% User Score Based on 50 reviews

Open The Gates! About the GameSidescrolling Castlebuilder. Real-time strategy game. The emperor has lost control over his kingdom! Now he has appointed you as the leader of a new conquest. Become a master of castle building and defense in this genre-blending sidescroller game. As you construct and fortify your fortress, you'll have a variety of defenses at your disposal, including walls, tower… If you enjoyed this game, see our list of games similar to Open The Gates!.

83%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, story

85% User Score Based on 54 reviews

Critic Score 77%Based on 2 reviews

Tactical-Action-RPG, mixing Turn-Based Tactics with Real-Time Action combat system. Use your mind to plan ahead and think about the best way to deal with your enemies. Use your skills to execute your actions and chain devastating combo until the last millisecond of your turn. If you enjoyed this game, see our list of games similar to Guild of Ascension.

89%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, optimization

89% User Score Based on 232 reviews

In the far future, Mankind has nearly exhausted all of earth’s natural resources. Fragile alliances between nations are tested to their limits as fierce wars ignite across land and space. MoonBase Commander puts you in charge of your own lunar territory in a quest to build the most powerful empire in space. Find, exploit and utilize valuable energy pools to eliminate rival factions. Choose the be… If you enjoyed this game, see our list of games similar to MoonBase Commander.

57%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, story

57% User Score Based on 130 reviews

Envy the Dead is zombie survival roguelike, in which you are leading group of unique, randomly generated characters through destroyed lands, infested with zombies. If you enjoyed this game, see our list of games similar to Envy the Dead.

85%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, grinding

85% User Score Based on 9,352 reviews

Dungeon of the Endless is a roguelike-like tower defense game. The player takes the role of survivors in a prison spaceship after its escape pods crash landed on a planet on their way to the Auriga system, which they were supposed to colonize as slaves. If you enjoyed this game, see our list of games similar to Dungeon of the Endless.

60%Game Brain Score

Most mentioned positive aspects:replayability, music

Most mentioned negative aspects:gameplay, monetization

60% User Score Based on 84 reviews

Control Craft 3 is a fast paced RTS, which brings quick thinking and clever tactics together for some planet conquering action. If you enjoyed this game, see our list of games similar to Control Craft 3.

69%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story, grinding

68% User Score Based on 235 reviews

Critic Score 73%Based on 2 reviews

The quiet hamlets of the Vale stand defenseless... No walls, no moats, not even a presentable fence. You'll have to use your resources wisely to transform each village from farm-town to fortress. Build defenses, train troops, and hold the line with powerful heroes in ValeGuard, a Defensive Strategy game. If you enjoyed this game, see our list of games similar to ValeGuard.

Bio Inc. Total Defense is an incremental tower defense game set inside your body. Command your immune system against massive hordes of viruses, bacteria, and other pathogens. Upgrade your defenses, place them wisely, and fight for every inch of your body. If you enjoyed this game, see our list of games similar to Bio Inc. Total Defense.

A traditional, turn-based roguelike. Descend through procedurally generated dungeons, fight unique bosses, hunt rare gear, and spend Faith to shape your run. Switch between ASCII and tiles on the fly. Fully playable with a controller and on Steam Deck. If you enjoyed this game, see our list of games similar to Faithfarer: The Cathedral.

LexiFront is an educational strategy tower defense game powered by English syntax. Deploy words onto sentence slots to construct your defenses: nouns provide firepower, verbs activate the line, and adjectives and adverbs enhance its performance. Through combat, review sessions, and story-driven reading, you will build familiarity with word meanings, parts of speech, and fundamental sentence struc… If you enjoyed this game, see our list of games similar to 句构远征-Lexifront.

The Horde has consumed humanity’s last line of defense. An unknown virus has swept across the globe. Cities have fallen, and civilization has collapsed. As a newly deployed operative, you are sent to the front lines of the infected zones, armed with weapons, tactical equipment, and defensive structures to protect humanity’s final hope against endless waves of the undead. Survive the Horde … If you enjoyed this game, see our list of games similar to Survive the Horde.

Short battles. Subtle decisions. Big consequences.Cardume is a real-time 1v1 card battler. Two swarms of thousands of living cells fight in a glowing arena. Steer yours with a handful of one-time cards. Lure the swarm onto a point, rally it into a charge, trigger a gorge, freeze an enemy assault. You can't micromanage individual cells, but a few well-timed plays ripple through thousands of them an… If you enjoyed this game, see our list of games similar to Cardume.

Humans fled to Solace seeking refuge from the eternal Celestial War. The name was a promise which was never kept. The war followed, and what they brought with them consumed everything. What remains is broken land, corrupted biomes, and desperate powers that call themselves salvation. You fight through what remains. Combat runs automatically. And when you die, that is not the end. That is the door… If you enjoyed this game, see our list of games similar to Tormented Souls Idle.

Total Battle is a war strategy game that will allow you to become immersed in a fantasy world of battles between ancient civilizations, magic kingdoms, and great empires. Join the legendary heroes of the mighty kingdoms and build your empire in the magical world of Total Battle! Total Battle is free to download and play, however, it contains in-app purchases, including random-item purchases. Enj… If you enjoyed this game, see our list of games similar to Total Battle: War Strategy.

We're planning to open our first Playtest this October! Add Aeriea to your Wishlist to get notified the moment it goes live. About This Game Pilot the fortress island you built with your own hands, crush the monster tides, and escape the floating archipelago! Aeriea is a laid-back action game that blends tower-defense building, roguelike, and survivor gameplay. With lightweight controls and… If you enjoyed this game, see our list of games similar to Aeriea.

Defense Of Village is a Roguelike strategy game that blends route selection with tower defense fortification. Craft unique defensive setups, face varied enemy types, and collect rule-altering relics to protect your village. Build Your Defense Choose your towers carefully! Each battle presents enemies with different traits. Will you pick off targets with Arrow Towers, burn groups with Magic Tower… If you enjoyed this game, see our list of games similar to Defense Of Village.

Towerlands – Ultimate Tower Defense Strategy & Simulation Step into the shoes of a mighty Lord in Towerlands, a rich blend of Tower Defense, Strategy, and Simulation gameplay. Build, expand, and defend your empire in a vast fantasy world of danger and opportunity. Fortify your fortress, command powerful armies, and embark on a journey of conquest and glory. ◉ Strategic Empire Building Develop yo… If you enjoyed this game, see our list of games similar to Towerlands: Tower defense (TD).

Luxmithar is a 2D survival defense roguelite built in Godot, where you defend a crashed forge-ship against escalating waves of hostile forces. Each run unfolds across multiple days as you harvest resources, expand a modular grid-based world, and construct layered defenses to hold back relentless alien incursions. If you enjoyed this game, see our list of games similar to Luxmithar.