Games like Germ Swarm: Evolution & Mutation

PLAYTEST NOW! Share your thoughts in the in-playtest feedback form and join our Discord community to help shape the future of Project: rEvolution Project: rEvolution is a fast-paced action-roguelike tower defense game built around dynamic turret control, modular upgrades, and evolving enemies. Each run gives you new tools, new modifiers, and new tactical problems to solve as you place, wield, a… If you enjoyed this game, see our list of games similar to Project: rEvolution.

Incursion is a sci-fi take on the classic horde survival game. Set in the near future, you’ll fight as a soldier of R.A.I.D. (Regional Anti-Incursion Defense). Unlock new classes and abilities as you battle an unrelenting swarm. Can you rise up and become a master of the battlefield? Features: 6 Unique Classes   18 Abilities that can be upgraded 3 Regions/Environments If you enjoyed this game, see our list of games similar to Incursion.

In 2039, the third global disaster will strike. Biochemical weapon viruses mutate under the influence of radiation, causing infected humans to lose their sanity and turn into berserk zombies. The old civilization collapsed with a roar, the entire land turned into perilous ruins, and the apocalypse restarts. The top-tier tech company Atlas launches a salvation plan. As the sole survivor of the exp… If you enjoyed this game, see our list of games similar to Doom Reignite.

Iimmerses yourself in a strategic battle within the human body, where you manipulate pathways and tower placements on a dynamic hexagonal grid. This educational tower defense game teaches players about the immune system through engaging gameplay, focusing on the defense against microscopic invaders.Key Features Path Expansion: Dynamically extend the pathways pathogens travel to strategically shape… If you enjoyed this game, see our list of games similar to STEM Defense.

Verfall: A Dark and Strategic RPGThe world of Verfall is in ruins. The "Servants of Corrosion" have been unleashed, and now it's a race against time to save what remains. Heroes marked by the "Mark" carry the burden of a curse and must unite, facing the challenge with the few resources available. Traditional power-ups are not an option — every battle must be fought with what yo… If you enjoyed this game, see our list of games similar to Verfall.

STARPHAGE takes the outbreak strategy of Plague-like games beyond planet earth and into an entire galaxy. Begin with one colonized star, shape a galactic pathogen through evolution, and turn isolated stellar outbreaks into a galactic extinction event before the galaxy can mount a response. In an age where life claims the stars, two forces compete for the galaxy.INTELLIGENCE - born of cooper… If you enjoyed this game, see our list of games similar to STARPHAGE: Galactic Plague Simulator.

Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

41%Game Brain Score

Most mentioned positive aspects:story, music

Most mentioned negative aspects:gameplay, graphics

70% User Score Based on 10 reviews

Starlight: Defence Command is a Tower Defence game designed for the PC that is tough and more in-depth than those gone before. With the ability to configure towers in billions of possible combinations, unlockable perks and fine tuning through target priorities, players are given powerful tools to complete the galaxy-spanning, story-driven campaign. If you enjoyed this game, see our list of games similar to Starlight: Defence Command.

Defeat the Rulers of the DeepUpgrade your crew, protect the locomotive, and keep the train moving. The deeper you travel, the harder it becomes to reach the next stop. Your Train Is Your FortressPath to Catakombs is an action-strategy roguelite about commanding a combat train through procedurally generated underground catacombs. Man the locomotive’s rotating gun, direct your crew’s fire, control… If you enjoyed this game, see our list of games similar to Path to Catakombs.

Incremental Heaven is a fast-paced action mix of incremental game and bullet heaven where every run transforms you from a weak beginner into an unstoppable force of destruction. Choose your character, fight endless waves of enemies, collect resources, unlock powerful upgrades, and evolve into forms that barely resemble where you started. But each character follows a completely different path. W… If you enjoyed this game, see our list of games similar to Incremental Heaven.

The world ended centuries ago. Kingdoms crumbled, knowledge vanished, and humanity was forced to begin again among the ruins of a forgotten age. In this harsh land, iron is more valuable than gold, ancient relics hold secrets no one understands, and every settlement fights to survive. Ashborn Empires is a unique co-op RTS/RPG hybrid where two players take on distinct but interconnected roles. On… If you enjoyed this game, see our list of games similar to Ashborn Empires.

"Infectious Disease" - Conquering the Human Body with the Body of a Virus!   - In 2030, the Nine-tentacles Fish Biotechnology company synthesized a completely new virus in the laboratory, which was used to test the ability of simple synthetic non-cellular life forms to acquire new genes，to verify whether the human-to-human transmission of this virus will exceed that of COVID-19 and mea… If you enjoyed this game, see our list of games similar to 传染病/Infectious Disease.

A top-down lightweight Rogue-like survivor game where players take on the role of a beast capable of evolving multiple times to fend off hordes of enemies. Choose from various evolution paths, talents, and skills build, survive against all odds, and ultimately evolve into the ultimate life form. The universe was primordial, and the world had just taken form, yet the innate beings were suffering fr… If you enjoyed this game, see our list of games similar to 洪荒进化 Hong Huang Evolution.

63%Game Brain Score

Most mentioned positive aspects:story, graphics

Most mentioned negative aspects:gameplay, optimization

90% User Score Based on 21 reviews

In the year 20XX...Humanity stands on the brink of extinction after a sudden alien invasion. The only hope: a final assault on the enemy’s central command, the Terminal Core.As commander of an elite special forces unit, you lead the desperate charge for survival. Features: Squad Management Simulation × Real-Time Tactical Battle You have just four weeks to forge your ultimate strike team before the… If you enjoyed this game, see our list of games similar to Live Hard, Die Hard.

Little Crimson Heroes is a cute 3D tower defense strategy game. The iron boots of the White Moon Federation have crossed the Hundred Flowers Field. Biochemical monsters, flesh machines, and mutated war vehicles are closing in on the Red Star Republic step by step. The homeland is in danger, and the flames of war have already been lit. Facing a powerful invader, the Red Star Republic has no path o… If you enjoyed this game, see our list of games similar to Little Crimson Heroes.

Zombie Epoch: Deck Apocalypse is a post-apocalyptic survival game that blends dungeon exploration with card-based strategy. As a survivor, you must venture into perilous ruins, scavenge scarce resources, build a powerful deck, and enhance your abilities to withstand relentless zombie hordes. Every expedition is a battle for survival, you must carefully choose your path, manage resources wisely, a… If you enjoyed this game, see our list of games similar to Zombie Epoch:Deck Apocalypse.

The Horde has consumed humanity’s last line of defense. An unknown virus has swept across the globe. Cities have fallen, and civilization has collapsed. As a newly deployed operative, you are sent to the front lines of the infected zones, armed with weapons, tactical equipment, and defensive structures to protect humanity’s final hope against endless waves of the undead. Survive the Horde … If you enjoyed this game, see our list of games similar to Survive the Horde.

Flesh long decayed, yet my spirit endures; Demon tides surge forth to drown every mortal realm. Battle lines interweave, war drums split the sky; We stand and fight to the last, longing to return home. One soul, awakens in a strange realm; two undead, band together to fight off endless swarming foes. NecroTide is a single-player turn-based survival loot ARPG with fast, tight combat. G… If you enjoyed this game, see our list of games similar to NecroTide.

PLAN. PREDICT. EXECUTE. Step into a surreal experiment where captive bio-organic entities are pitted against each other. Compulse is a simultaneous tactical roguelite where you'll build a squad of Compulsors and throw them into a brutal test of evolution and mutation. Plan your moves, predict the enemy's, then watch both squads act at once, turn after turn. Steal your opponents' power to survive a… If you enjoyed this game, see our list of games similar to Compulse.

Autonomous Warfare Evolution is a real-time strategy simulation where you evolve and deploy swarm-intelligence autonomous weapons using genetic algorithms.Swarm Intelligence Evolves Across GenerationsThe performance and behavioral parameters of swarm-intelligence autonomous weapons—such as vision, attack range, mobility, and formation tactics—are encoded as genomes. Genomes in the pool engage in u… If you enjoyed this game, see our list of games similar to Autonomous Warfare Evolution.

Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

Seize control over an entire species and shape its destiny!In Genetica: Extinction, you are a researcher conducting experiments inside a closed artificial ecosystem. Your task is to observe, manipulate, and guide a population of creatures as they struggle to survive in an ever-changing environment. Your goal is simple - prevent total extinction. The ecosystem reacts to every decision you make. Hu… If you enjoyed this game, see our list of games similar to Genetica: Extinction.

Alien's Fridge One slip sparks fear, one misstep makes it clear. Overview: Alien's Fridge is a 2D roguelike horror physics-based platformer where you step into the shoes of a brave boy scout trapped in a cave infested with ravenous aliens. Fight for your survival as you gather crucial upgrades and face a formidable final boss in this relentless battle. Gameplay Intense Challenge: Every level ra… If you enjoyed this game, see our list of games similar to Alien's Fridge.

You are the last salvager. Pilot your ship into hostile sectors, recover what others left behind, and fight your way back to the Forge before everything is lost. Starforge Reborn is a gritty top-down 2D action roguelite built around high-pressure combat, salvage-driven progression, permanent upgrades, and difficult risk-reward decisions. Push deeper into collapsing space, extract with your haul… If you enjoyed this game, see our list of games similar to Starforge Reborn.

Clicker Arsenal is not just about watching numbers go up; it's about evolving the art of war. Start your journey in the stone age with a Slingshot and advance through technological eras until you command the cosmic power of a Galaxy Destroyer. In this Idle Game hybrid with Tactical Strategy, your Ammo is more than money — it is the fuel that powers your victory. ARSENAL EVOLUTION Unlock and upgr… If you enjoyed this game, see our list of games similar to Clicker Arsenal.

Infect. Evolve. Ascend.Alpha Genesis is an action roguelite where you guide a cosmic viral organism through a process of continuous evolution, combat, and transcendence. You control the virus directly: move with WASD, aim and activate abilities with the mouse. Every second requires tactical decisions as you navigate through hordes of immune cells, collect resources, and grow your colony. CORE GA… If you enjoyed this game, see our list of games similar to Alpha Genesis.

98%Game Brain Score

Most mentioned positive aspects:gameplay, replayability

Most mentioned negative aspects:story, graphics

98% User Score Based on 144 reviews

A turn-based roguelite unlike anything you've played beforeDive into the microscopic world - cure the virus ravaging the planet. In Cell Command, units grow when they move, and attacks shrink them. A "tank" could be a long, winding python that clogs up the battlefield & encircles its prey!     Mix DNA nucleotides A C G T to discover unique, unicellular combatantsCommand c… If you enjoyed this game, see our list of games similar to Cell Command.

At the twilight of the apocalypse, will you be a Zombie Herder, or humanity's Savior?In a crowd, those who stand apart often invite envy or jealousy; those who are stronger may find themselves demanded of even more. Even seclusion in mountain forests cannot sever the world's shackles completely. Ten years ago, a biochemical virus swept across the globe. Though humanity fought back with all its mi… If you enjoyed this game, see our list of games similar to Zombie Self-Cultivation.

AN ACTIVE INCREMENTAL TOWER DEFENSEHow to Turn Zombie combines incremental progression, tower defense pressure, and direct cursor-based combat. Attack cells directly with your cursor Defend your central Viral Core Harvest Biomass and unlock permanent mutations Build powerful upgrade synergies Adapt to new mechanics across different organs Face increasingly dangerous immune defenses and… If you enjoyed this game, see our list of games similar to How to Turn Zombie.

Perihelion is a physics-based space combat roguelite where gravity is your greatest weapon. Launch from your carrier, execute high-speed orbital combat missions, and evolve your ship build run by run — solo or with your squad of up to 4 players. Master Orbital CombatAt first glance, space combat looks simple: aim, shoot, survive. But in Perihelion, nothing moves in a straight line for long. You… If you enjoyed this game, see our list of games similar to Perihelion.

Fight Directly. Build Systems That Keep Working. Action & Automation is a 2D side-scrolling action-RTS. Control a Commander on the battlefield while Flux and Forge build systems that produce units, move resources, and keep applying pressure. Shade takes a different route: she has no conventional base and turns infiltration, sabotage, and control into her war machine. Switch between direct com… If you enjoyed this game, see our list of games similar to Action & Automation.

YOU'RE NOT THE SHIPHumanity has discovered vast fields of gold drifting through deep space. Every prospector wants a piece of it. You're not safely behind the controls of a spaceship. You're a fragile astronaut with a jetpack and laser, floating beside your own cargo hauler. Step into the vacuum. Mine gold. Make it home alive. MINE IT. HAUL IT. PROTECT IT.Every expedition sends you into an aste… If you enjoyed this game, see our list of games similar to Cosmic Gold Rush.

LAST SHINOBI : A TACTICAL STRATEGY-BUILDING ROGUELIKEMaster the art of war in the shadows THE EXPERIENCEDive into a tactical roguelike where every decision counts. Embody a ninja and traverse hostile locations to eliminate your targets. Build a unique strategy, unlock new skills and companions, and refine your synergies to overcome your enemies. Each run is unique, each level is a strategic puzzle… If you enjoyed this game, see our list of games similar to Last Shinobi.

Discover a shattered continent where maddened fragments of the Sovereign's soul spread their cursed influence across every corner of the land. Face them in tactical turn-based battles where every choice can be fatal and every mistake unforgivable. As you level up, you will choose from random upgrades across three distinct skill trees; the deeper you go in one, the stronger and rarer the buffs beco… If you enjoyed this game, see our list of games similar to The Sovereign.

Darkness invades the world, and the light of the entire continent is devoured. Somewhere in the world, the last magical lighthouse shines its final light. Guard it, for it is the last hope of this world! Meow Tower - Doomsguard is a game rich in roguelike elements. The instant changes and strategies during battles will determine whether you win or lose. It is a strategic RPG game that combines … If you enjoyed this game, see our list of games similar to Meow Tower - Doomsguard.

Glory DefenceGenre: Action, Shooter, Survival Modes: Single-player, Multiplayer Platform: PC ABOUT THIS GAMEGlory Defence is a fast-paced zombie survival shooter set in a post-apocalyptic world overrun by a deadly virus. As the infected turn into relentless zombies, humanity teeters on the edge of collapse. Elite special forces are deployed to defend the last fortified zones and protect the remai… If you enjoyed this game, see our list of games similar to Glory Defence.

Take control of the body’s defense system in this fast-paced action shooter. Step into the role of a powerful immune cell and use precise touch controls to target and eliminate waves of invading bacteria and viruses. If you enjoyed this game, see our list of games similar to BODYguard: CellWars.

Kaelisia is being consumed sector by sector. The Stato Front is advancing, and every mission is vital to hold the line, recover critical resources, and push the invasion back. Enlist as an elite pilot in Drone Armada, and command massive drone swarms in real-time action-strategy battles. Lead your primary swarm into combat, direct supporting units across the battlefield, research powerful techn… If you enjoyed this game, see our list of games similar to Drone Armada.

Math Dungeon Quest is a retro-style fantasy RPG where solving math problems is the key to survival. Explore a procedurally deepening dungeon filled with enemies, treasure, and challenges that test your mental agility. Every correct answer unleashes powerful attacks, while mistakes can leave you vulnerable to enemy strikes. You take on the role of a lone adventurer navigating a magical dungeon … If you enjoyed this game, see our list of games similar to Math Dungeon Quest.

62%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

100% User Score Based on 13 reviews

You are the only male survivor in this universe. A fast-paced RTS featuring galactic conquest. If you enjoyed this game, see our list of games similar to Millennium Conflict.

The Enemy Is Evolving. So Must You. Invaders Evolutions transforms the classic fixed-screen alien shooter into a run-based, 100-level arcade survival war with no permanent power creep. You are humanity's last defensive line, fighting through a dark retro-industrial invasion toward the final Mothership encounter. Moment to moment, it is fast, readable arcade action: slide the turret through incom… If you enjoyed this game, see our list of games similar to Invaders Evolutions.

Deck of Destiny: Battleforge Deck of Destiny: Battleforge is a modern roguelike deck-builder that combines elements of strategy, action, and roguelike deck-building. Choose one of four legendary heroes to reclaim the magic of the ancient lands and prepare to write your own legend in an endless war. In this strategic game, test your skills in clever card usage and effective strategy development … If you enjoyed this game, see our list of games similar to Deck of Destiny: Battleforge.

28%Game Brain Score

Most mentioned negative aspects:gameplay

44% User Score Based on 16 reviews

ELARIENNE: Strategy decides the battleOne summon can change the flow. Unpredictable variables form your army, and only precise strategy carries you to the end. All unit summons are random, from common tiers to ultra-rare ones. 8 tiers in total, and 3 races: human, elf, and orc. Each race has a completely different combat style, making every team build fresh and unpredictable. Want to crea… If you enjoyed this game, see our list of games similar to ELARIENNE.

55%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

87% User Score Based on 15 reviews

Gelluloid Domination is a fast-paced strategy game of fantasy biology. Start with a single fragile cell and expand across the network, assimilating rivals to grow your gel-powered army. Evolve mutations, unlock new abilities, and outmaneuver deadly pathogens. Adapt and conquer, expand or be consumed. Every decision shapes the network — will you achieve total domination? If you enjoyed this game, see our list of games similar to Gelluloid Domination.

75%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, music

75% User Score Based on 478 reviews

Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy. If you enjoyed this game, see our list of games similar to Defend Your Life: TD.

Orange Dawn: World Description  Team: Team Orange for GSD 405 at UIUC SP 2023 Team Members: David Zhu, Tom Jiang, Yifeng Ni, Fransico, Marta Art Style: pixel art Tone: dark, gloomy setting Environment After an outbreak of a virus in 203X, the virus has turned people into zombies. In the apocalyptic world, metropolitan areas are overrun with the infected, and people try to survive in the less po… If you enjoyed this game, see our list of games similar to Orange Dawn.

The Blood Moon descends, and the mortal realm falls into purgatory. The Lord of Lingxu Palace burns away body and soul, reshaping the cultivators’ forms, granting a seven-day reprieve. Baptized in blood and fire, they stand with no way back. Break the siege, slay the fiends, and overturn the heavens! A Seven-Day Last Stand In the seventh year of Zhushang, the heavens shuddered as the Blood Mo… If you enjoyed this game, see our list of games similar to Blood Moon: Last Stand.

【神兵武装，逆天改命】 获取特殊武器，印记，并分别升到满级，合成威力超强的武器，享受极爽刷怪体验！ 【女神系统，羁绊觉醒】 攻克“龙皇女神”，“凤凰女神”等5位美艳女神，强强联手，共同退敌！ 【史诗战场，火力全开】 横跨武侠妖魔世界的终极试炼：从武林废墟到妖魔领地，50种妖魔鬼怪，15个魔头BOSS。无限挑战模式+roguelike天赋树，真正定义末日生存美学！ 【开发者寄语】 30小时主线内容+无限重玩价值，快邀请你的本命女神，开启逆天改命的传奇征程！ If you enjoyed this game, see our list of games similar to 武侠幸存者.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

Crystant is a top-down post-apocalyptic survival strategy game. You awaken as a “test subject” inside a mysterious facility buried deep underground. You will explore the unknown depths of the earth, using resources and strategy to overcome various mutated creatures. Each expedition is a completely new challenge. Random events, deadly traps, unknown areas, and risk-reward route choices all combine … If you enjoyed this game, see our list of games similar to Crystant.