Games like Germ Swarm: Evolution & Mutation

96%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:grinding, stability

96% User Score Based on 1,665 reviews

You are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host's immune system. Conquer a beautiful, procedurally generated world of tiny proportions. If you enjoyed this game, see our list of games similar to Pathogenic.

Command. Survive. Evolve.You are the last Biocore Pilot — a survivor stranded on a dying alien world. Your only hope lies within the Biocore system, an ancient technology capable of creating life, weapons, and power beyond human understanding. But every pulse of energy draws swarms of hostile creatures closer. Survive long enough to rebuild, upgrade, and uncover what remains of humanity’s final ou… If you enjoyed this game, see our list of games similar to Core Remnants.

An infection has struck the body! As the mighty T-Cell, it's your duty to eradicate the invading pathogens! Consume pathogens to earn mito energy, and use it to purchase upgrades and summon allies in your battle to protect the body. If all your body cells die, it's game over for you. Utilising squishy softbody physics and hand-drawn graphics, this game will take you on a journey through the body… If you enjoyed this game, see our list of games similar to Going Viral.

55%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

87% User Score Based on 15 reviews

Gelluloid Domination is a fast-paced strategy game of fantasy biology. Start with a single fragile cell and expand across the network, assimilating rivals to grow your gel-powered army. Evolve mutations, unlock new abilities, and outmaneuver deadly pathogens. Adapt and conquer, expand or be consumed. Every decision shapes the network — will you achieve total domination? If you enjoyed this game, see our list of games similar to Gelluloid Domination.

Manage a spooky castle of monsters & fend off angry mobs with Slingshot action in this Physics-based Tower-Defense RTS. Fling vampires, mummies, & more to make the local villages crumble. Upgrade your units & castle between battles for impenetrable defenses & cause monstrous destruction! If you enjoyed this game, see our list of games similar to Mobs 'N Monsters.

Weave through enemy swarms, slay them for their souls, consume souls to cast summoning magic, merge allies to increase their power, and use sigils to reshape the next swarm. In this fast-paced survivors-like, survival is a skill you master. Enemies close in from every direction forcing you to weave, reposition, and think ahead while your allies unleash relentless attacks on their own. Every kill… If you enjoyed this game, see our list of games similar to HUDDLE BATTLE.

Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

CAN YOU DESTROY HUMANITY?Micro-scale evolution. Macro-scale extinction. Patient Zero is an idle/incremental pandemic strategy where you engineer ever-evolving biological threats. As the architect of collapse, min-max your mutation layers to ensure the world succumbs to your design. THE LOOP OF DESTRUCTIONMaster a progression cycle built for massive scaling: Harvest: Gather Biomass to fuel expan… If you enjoyed this game, see our list of games similar to Patient Zero: Plague Idle.

80%Game Brain Score

Most mentioned positive aspects:gameplay, music

94% User Score Based on 36 reviews

Discover the beauty and fragility of life in Survivor Cells, a unique survival game against viruses and bacteria, which strategically combines the elements of roguelite, bullet hell and tower defense in a challenging experience. Your destiny depends on your agility and choices. How far will you get? If you enjoyed this game, see our list of games similar to Survivor Cells.

79%Game Brain Score

Most mentioned positive aspects:gameplay, story

Most mentioned negative aspects:grinding, replayability

79% User Score Based on 690 reviews

Critic Score 80%Based on 1 reviews

A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding. If you enjoyed this game, see our list of games similar to Infectonator 3: Apocalypse.

89%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:replayability, optimization

89% User Score Based on 281 reviews

Xenopurge is a tactical auto-battler where you are a Commander tasked with purging the Xenos threat. Operate from a remote command center, issuing indirect orders via multi-screen interfaces. Plan routes, set priorities, and adapt as missions escalate and feel the true weight of being in command. If you enjoyed this game, see our list of games similar to Xenopurge.

63%Game Brain Score

Most mentioned positive aspects:story, graphics

Most mentioned negative aspects:gameplay, optimization

90% User Score Based on 21 reviews

Busy but Addictive! This BATTLE x MEDICAL Counter-Invasion Real-Time Strategy is like nothing you've ever seen! An army of aliens is here to invade the Earth! Show the Earth-style greeting to those unwanted visitors who lounge around our grounds! Lead your troops to extinguish zillions of aliens! If you enjoyed this game, see our list of games similar to Live Hard, Die Hard.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

The Horde has consumed humanity’s last line of defense. An unknown virus has swept across the globe. Cities have fallen, and civilization has collapsed. As a newly deployed operative, you are sent to the front lines of the infected zones, armed with weapons, tactical equipment, and defensive structures to protect humanity’s final hope against endless waves of the undead. Survive the Horde … If you enjoyed this game, see our list of games similar to Survive the Horde.

Sivers is an RPG-roguelike with a unique style, where waves of enemies test your strategy. Use spells and build defenses, develop your hero, and fight bosses and varied foes. Victory on the first try is unlikely — every attempt brings you closer to success! If you enjoyed this game, see our list of games similar to Sivers.

BIOLOGY IS THE ULTIMATE SANDBOXWelcome to the Vanguard Initiative. STEMMIES™ is not just a medical simulator; it is a living, breathing kinematic ecosystem that exists directly on your screen. Powered by the proprietary TitanEngine™, you are tasked with managing a complex biological metropolis, tracking pathogen vectors, and building an unstoppable medical empire. Bio-Economic Domination: Tr… If you enjoyed this game, see our list of games similar to Stemmies.

NEON TWIN-STICK • BULLET HELL ROGUELIKE Become insanely overpowered in a Tron-style neon grid where swarms never stop. Stack broken upgrades, melt thousands of robotic enemies, complete high-risk side objectives, and deliberately break the balance to dominate the simulation. If you enjoyed this game, see our list of games similar to Mega Trons Survivors.

85%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:replayability, story

85% User Score Based on 484 reviews

Sipho is an action survival game with an intricate building system. Grow your own creature and take over the local ecosystem. Fight, grow, survive, dominate. If you enjoyed this game, see our list of games similar to Sipho.

68%Game Brain Score

Most mentioned positive aspects:graphics, replayability

Most mentioned negative aspects:gameplay, grinding

84% User Score Based on 32 reviews

Blast through the zombie apocalypse in this top-down action roguelite! Take control of a deadly train, aim your primary weapon, gather resources with drone support, rescue survivors, and upgrade your firepower strategically. Unlock new locomotives, powerful weapons, and terrifying bosses. Choo Choo Survivor 2 blends horde survival and strategic upgrades in a unique experience inspired by games … If you enjoyed this game, see our list of games similar to Choo Choo Survivor 2.

92%Game Brain Score

Most mentioned positive aspects:atmosphere, character development

Most mentioned negative aspects:gameplay, story

92% User Score Based on 50 reviews

After defeating Fujin and Raijin, Hiro and his allies found peace at his grandfather’s house. One day, Sanbi sensed a distant summon. After tracing the energy, they discovered it came from her true form—the nine-tailed fox. Determined to help, Hiro and his friends set off on a new journey. If you enjoyed this game, see our list of games similar to Yokai Art 2: Tales of the Nine-Tails.

86%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, replayability

86% User Score Based on 109 reviews

Defend your Chrysalis from growing hordes of monsters in this hybrid game that combines elements of tower defense, survival, and roguelike RPGs. Explore procedurally generated levels, possess and control animals, and grow deadly gardens. How far can you get before the next wave of monsters attacks? In Chrysalis, you play the role of an incorporeal Wisp tasked with defending a magical Chrysalis fr… If you enjoyed this game, see our list of games similar to Chrysalis.

77%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, story

77% User Score Based on 166 reviews

Bioweaver is an RPG game with the main content of treasure hunting and character building. You can use basic programming logic to deeply customize your skill sets, and you can also create organs with different attributes and functions with the special crafting system. If you enjoyed this game, see our list of games similar to Bioweaver.

35%Game Brain Score

Most mentioned negative aspects:gameplay, graphics

60% User Score Based on 10 reviews

Our Discord- - *Wild Legion es parte de Erabit's Bud Scheme, un espacio para la creatividad de juegos y desarrolladores en solitario/equipos pequeños para prosperar. If you enjoyed this game, see our list of games similar to Wild Legion.

85%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, grinding

85% User Score Based on 9,352 reviews

Dungeon of the Endless is a roguelike-like tower defense game. The player takes the role of survivors in a prison spaceship after its escape pods crash landed on a planet on their way to the Auriga system, which they were supposed to colonize as slaves. If you enjoyed this game, see our list of games similar to Dungeon of the Endless.

74%Game Brain Score

Most mentioned positive aspects:gameplay, humor

Most mentioned negative aspects:story, graphics

74% User Score Based on 169 reviews

BossConstructor is a game about building and flying your own spaceship!Building your Ship. The core feature of the game is its ship editor which allows you to freely assemble your own spaceships using a vast variety of modules (currently more than 60). The way you build your ships determines how they behave and what they are capable of doing. Since every module costs money, weight and energy, desi… If you enjoyed this game, see our list of games similar to BossConstructor.

Your beloved tangerine has been kidnapped… by vegetables! Play as Orangino in a chaotic fight against vegetable foes to rescue his kidnapped tangerine girlfriend. Orangino must fight through randomized levels filled with attacking veggies, choosing from an eclectic arsenal of weapons: medieval bows and slings, modern guns like AK-47s and bazookas, and magical staffs and wands. Each run is a f… If you enjoyed this game, see our list of games similar to Orangino.

Master physics-driven flight as you explore hostile alien territory. Gather resources, upgrade your ship, build and defend your base, destroy enemy strongholds, and recover mysterious Orbs. If you enjoyed this game, see our list of games similar to Thrust: The Hunt.

COMMAND THE ULTIMATE DEEP SPACE FORTRESS! Embark on a perilous journey into the dark abyss of outer space. In this endless sci-fi tower defense game, you are the Commander of a high-tech starship cruising through hostile galaxies. Cosmic monstrosities and alien hordes are closing in from the void, drawn to your ship's energy core. You and your elite crew are the final line of defense between surv… If you enjoyed this game, see our list of games similar to We Grow Together.

Luck is on your side! Battle on the edge!"Miraclawns" is a roguelite strategy game that fuses "gambling" with "real-time strategy." In this world, strengthening slimes isn't about grinding for XP or level-ups. Everything is decided by gambling. Send your squad of slimes, empowered by high-stakes bets, into a battlefield swarming with vicious monsters. Victory might no… If you enjoyed this game, see our list of games similar to Miraclawns.

⚠ CONTAINMENT FAILURE IMMINENT A Tactical Sci-Fi Horde Survival Roguelike where every strategic choice matters. Suppress a rapidly evolving biological outbreak consuming a fallen military research complex. Fight alongside HELIOS, a damaged tactical AI whose forecasts grow less reliable with every passing Dawn. Deploy orbital defenses, fuse experimental technologies, engineer devastating weapon b… If you enjoyed this game, see our list of games similar to Deep Breach.

AUTO-BATLLER Real-time combat. Your ship auto-fires while enemies swarm in escalating waves. Each sector increases danger, introducing elites and ambushes that punish or reward greedy builds. INCREMENTAL UPGRADE Earn XP from every encounter and invest it into permanent, incremental meta upgrades. Prestige to unlock new ships and return stronger for the next run. PICK-1-FROM-3 … If you enjoyed this game, see our list of games similar to Void Salvage.

Loot & Reboot Genre: Fast-paced 3D Top-Down Roguelite Shooter. The Hook: Step into the neon-drenched chaos of Loot & Reboot, a relentless survival shooter where your ability to scavenge and adapt is the only thing standing between you and a system crash. In a world of sentient scrap and lethal algorithms, you must fight through procedurally generated combat zones, upgrade your arsenal, and pus… If you enjoyed this game, see our list of games similar to Loot & Reboot.

Embark on a challenging journey where tactical depth meets randomness. Designed for Steam Deck (But you can play with any controller or mouse and keyboard if you like) use the trackpad to hover over stats for richer, mouse-like descriptions. Experience a unique fusion of roguelike discovery and JRPG combat systems, where every decision matters. Strategic Combat System Break free from min… If you enjoyed this game, see our list of games similar to Depthbound Descent.

Face relentless swarms of AI-controlled invaders in this sci-fi survival roguelite. As a soldier of R.A.I.D. (Regional Anti-Incursion Defense), wield and upgrade devastating abilities to annihilate your foes. Do you have what it takes? If you enjoyed this game, see our list of games similar to Incursion.

Take on the challenge and discover a completely new 3D sci-fi dungeon crawler. The sophisticated room card mechanics and endless generated dungeons with the form of a cube, this game is unique in this genre. What will you discover while exploring? If you enjoyed this game, see our list of games similar to Cube Crawler.

WHEN THE WORLD ENDS, LEGENDS ARE BORN Experience the most addictive zombie survival game that will keep you coming back for "just one more run." Combine intense bullet-hell action with deep progression systems in a game where every decision matters and every run makes you stronger. MASSIVE WEAPON ARSENAL - YOUR SURVIVAL, YOUR STYLE 4 Permanent Weapons: From rapid-fire Machine Gu… If you enjoyed this game, see our list of games similar to Zombie Survivor.

Life Altered is a nature based roguelike deckbuilder that blends cards and dice gameplay. Evolve your animal and plant cards multiple times to truly overpowered levels: Maul your enemies with a genetically enhanced honey badger or send them into a world of never-ending pain with the bullet ant. If you enjoyed this game, see our list of games similar to Life Altered.

Lead a squad deep into the ruins of the city. Scavenge for resources atop the remnants of the old civilization, and use the ruins to fend off the Swarm. In this unique salvage-and-defend strategy game, you will gradually uncover the source of the Calamity and rebuild human civilization. If you enjoyed this game, see our list of games similar to Under the Ruin.

A tower defense rogue-lite where the battlefield is yours to shape. An ancient evil has awakened, and the Blight is spreading across the land. As a Guardian of the Arcanum, you wield the only weapon capable of pushing it back. In a desperate last stand, defend the realm by building towers, casting powerful spells, reshaping the terrain, and stop the Blight at its source. Reshape the Battlefie… If you enjoyed this game, see our list of games similar to Stop the Blight.

Survive an endless undead horde in this brutal auto-battling roguelike. Slash, upgrade, and evolve your arsenal as chaos unfolds to the pulse of an industrial metal soundtrack. Contagion Protocol is fast, bloody, and built for replayability. If you enjoyed this game, see our list of games similar to Contagion Protocol.

Verfall: A Dark and Strategic RPGThe world of Verfall is in ruins. The "Servants of Corrosion" have been unleashed, and now it's a race against time to save what remains. Heroes marked by the "Mark" carry the burden of a curse and must unite, facing the challenge with the few resources available. Traditional power-ups are not an option — every battle must be fought with what yo… If you enjoyed this game, see our list of games similar to Verfall.

59%Game Brain Score

Most mentioned positive aspects:gameplay

Most mentioned negative aspects:optimization

100% User Score Based on 10 reviews

Survive thousands of monsters in X-Mutation, a hardcore 3D top-down rogue-lite action game. Mutate your body into diverse weapons, choose from hundreds of mutations, and uniquely upgrade to craft your personal combat style! If you enjoyed this game, see our list of games similar to X-Mutation.

Lead an ever-evolving cosmic virus in this action roguelite: infect, fuse your cell into new shapes, choose your abilities, ascend without limit and conquer entire planets. If you enjoyed this game, see our list of games similar to Alpha Genesis.

Spend Magic Stones to summon elf girls with unique abilities and fight back the invading goblin army. Defeat goblins to earn more Magic Stones, upgrade your defense towers, and strengthen your power. Lead your girls to cast powerful magic, defeat the Goblin King, and save the fantasy world! If you enjoyed this game, see our list of games similar to Girls vs Goblins.

Face endless hordes in this bullet hell! Choose from 41 characters and battle your way through 50 maps. The karma system is key: your actions control the evolution of your weapons. Will you shine as a holy warrior or devour the world as a dark lord? If you enjoyed this game, see our list of games similar to Void Vow.

Defend the body in vaXinator, a fast-paced action roguelike! As the last white blood cell, unleash powerful abilities and antibodies to fight off waves of infections. Test your reflexes in this microscopic battle for survival. How long can you hold the line? If you enjoyed this game, see our list of games similar to vaXinator.

Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

60%Game Brain Score

Most mentioned positive aspects:gameplay, character development

Most mentioned negative aspects:story, graphics

89% User Score Based on 18 reviews

A sci-fi Vampire Survivors-like shooter. Control mecha girls to fight terrifying bug swarms. 40+ unique weapons & hundreds of passive skills for diverse Builds. Features space base management, mecha girl development, Live2D healing massages, and 4-player co-op. Enjoy interstellar survival adventures If you enjoyed this game, see our list of games similar to Girl Frame.

70%Game Brain Score

Most mentioned positive aspects:graphics, replayability

Most mentioned negative aspects:gameplay, grinding

87% User Score Based on 31 reviews

Drive your train through the zombie apocalypse, gather resources, rescue survivors, and upgrade your train strategically into a powerhouse of destruction. Defeat the boss and get to the end to win, or complete the survival challenge! If you enjoyed this game, see our list of games similar to Choo Choo Survivor 2.