Games like CRISPR Defense

Take control of the body’s defense system in this fast-paced action shooter. Step into the role of a powerful immune cell and use precise touch controls to target and eliminate waves of invading bacteria and viruses. If you enjoyed this game, see our list of games similar to BODYguard: CellWars.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

55%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

55% User Score Based on 102 reviews

Take control of a determined White Blood Cell on a quest for self discovery, vengeance, punishment and annihilation of all evil germs who would dare infiltrate an unsuspecting and innocent human body in this unique and organic experience. Battle evil germs by slamming into them, using your Powerbutt ability to further enhance the damage and pain inflicted. If you enjoyed this game, see our list of games similar to Germ Wars.

AN ACTIVE INCREMENTAL TOWER DEFENSEHow to Turn Zombie combines incremental progression, tower defense pressure, and direct cursor-based combat. Attack cells directly with your cursor Defend your central Viral Core Harvest Biomass and unlock permanent mutations Build powerful upgrade synergies Adapt to new mechanics across different organs Face increasingly dangerous immune defenses and… If you enjoyed this game, see our list of games similar to How to Turn Zombie.

In Circuit Keep, the intrusions walk straight over your towers. So you don't stop them with firepower — you carve their routes yourself. It's a maze tower defense game inside a living circuit lattice, with no fixed paths. INTRUSIONS breach from BREACH POINTS and pathfind toward your CORE across an open grid. You wall that grid into a killing maze with FIREWALLs, line the routes with damage, and fo… If you enjoyed this game, see our list of games similar to Circuit Keep.

Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

In DC3: Viral Menace, you play as Dr. Vidya Vichaar, battling a viral infection ravaging her daughter's body. Zoom through artfully crafted levels themed as pages of a comic book in Vidya's magnificent technological ship - The Caper-5000. Navigate various systems of the human body in this top-down, isometric adventure. Begin in the cavernous respiratory system, descend into the acidic digestive s… If you enjoyed this game, see our list of games similar to DC3: Viral Menace.

Bioneers – Game Features Unique gameplay that combines factory-building with organism simulation. Instead of buildings — cells, instead of conveyor belts — vessels, instead of enemies — viruses. The bigger your organism, the more powerful it becomes — but it also needs more resources to sustain itself. Animations inspired by real biology. All cell and system movements are based on behavioral mod… If you enjoyed this game, see our list of games similar to Bioneers.

A virus is attacking your cells, and its up to you to defend them! Buy and combine cells to assemble your immune response. Discover powerful synergies to overcome a constantly evolving enemy in this physics-based auto battler. Build an ironclad immune defense in 10 turns or perish.Create the ultimate immune response Create the ultimate immune response: Combine immune cells in interesting ways to o… If you enjoyed this game, see our list of games similar to Auto Immune.

# BIOFIGHTERS [Watch the BIOFIGHTERS Trailer on YouTube]( ) ## Overview **BIOFIGHTERS** is an action-packed educational game that immerses players in the world of the immune system. Players take control of different immune cells, each with unique roles, to defend the body against increasingly dangerous pathogens. The game is structured into two mini-games and one larger level, forming a co… If you enjoyed this game, see our list of games similar to BIOFIGHTERS.

Jagoan N3on presentsControlling the immune system forces with unique abilities, and defending the lungs from deadly threats in a battle for human health. It's a unique and exciting gaming experience to safeguard the lungs from virus attacks and support the goals of Health and Well-being in the Sustainable Development Agenda. In this game, there will be two modes: Hack and Slash, as well as Tower … If you enjoyed this game, see our list of games similar to Lung Defender: The Tuberculosis Battle.

Just as the COVID-19 pandemic is starting to sweep through the world, Antidote Laboratories receives a strange package. You are assigned to study it and WHAM!, get thrown into the frontlines of medical science. Based on real events and loaded with useful facts about COVID-19, the Antidote COVID-19 takes you on a science adventure! • Defend the stem cell against viruses and bacteria • Build your o… If you enjoyed this game, see our list of games similar to Antidote COVID-19.

"Inoculation: Defend the Body" is an immersive tower defense game set within the intricate landscape of the human body. Players embark on a crucial mission to protect the body from relentless waves of invading pathogens seeking to cause chaos and illness. The game unfolds within the intricately designed environments representing vital organs, bloodstream passages, and cellular structures. Each … If you enjoyed this game, see our list of games similar to Inoculation.

English:Hey you! ViralAttack is a game where you have to control the immune system to defend the healthy cells from the attacking viruses. After every wave of viruses you have the possibility to buy new defender-cells with upgrades in Range, Hitrate, Speed and Damage.  Therefore you use points, which you receive ingame for defending your healthy cells. If a virus infects an healty cell, the infect… If you enjoyed this game, see our list of games similar to ViralAttack.

We decided to make the alpha free for anyone to download!  Please join our Discord here if you want to give some feedback or require any support! GAMEPLAY VIDEO - this will help you get started QUICK START GUIDE - ALPHA  The current build can be a little bit overwhelming because it's a pure sandbox experience in which you are on your own to understand the mechanics, we're currently working on a … If you enjoyed this game, see our list of games similar to Lifecraft.

45%Game Brain Score

Most mentioned negative aspects:gameplay

69% User Score Based on 16 reviews

Your Human is sick and it's up to you, a naive T Cell, to solve puzzles, fight off bacteria and viruses, and learn about the immune system. Make your human healthy again in this dungeon crawler adventure! If you enjoyed this game, see our list of games similar to Your Human is Sick.

Welcome to the Human Immunity Command Center~ As a new commander, you must command cells to attack, defeat invading bacteria and viruses, and defend body cells. Be careful! Some immune cells could be too powerful to kill everything, including our original cells! Here, you can produce different immune cells, deploy your resistant cell line of defense, learn how bacteria and viruses damage human cel… If you enjoyed this game, see our list of games similar to 战地细胞（Battlefield Cell）.

63%Game Brain Score

Most mentioned positive aspects:gameplay, monetization

Most mentioned negative aspects:stability, music

63% User Score Based on 303 reviews

Take the Field. Command the Offense. Forge Your Football Legacy. If you enjoyed this game, see our list of games similar to Ultimate QB: Football Legend.

A 4-player co-op endless TD game with rotating lanes. Choose from a wide variety of towers, equip powerful items to enhance their abilities, and survive 50 waves of enemies, including 4 mini-bosses and 1 final boss, across 5 difficulty levels. If you enjoyed this game, see our list of games similar to 保卫实验室 (Defend the Lab).

A pirate-themed tower defense + roguelite game set across hexagonal archipelagos. Play as a newly arrived island lord: build defenses, expand your islands, unlock power-ups, and fend off hordes of greedy pirates to protect the treasure at the heart of your islands. After each defeat, return to the harbor with your accumulated gems to unlock stronger starting builds and structures — and ta… If you enjoyed this game, see our list of games similar to Treasure's Mine!.

94%Game Brain Score

Most mentioned positive aspects:story, graphics

Most mentioned negative aspects:gameplay, monetization

94% User Score Based on 53 reviews

Antivirus Girl is a defense shooter game where you become an inspector for the anti-malware Sentinel to protect computers from malware. Inspect files coming in from the network, let safe files pass through, and immediately eliminate malware. If you enjoyed this game, see our list of games similar to Antivirus Girl.

51%Game Brain Score

Most mentioned negative aspects:gameplay, grinding

67% User Score Based on 27 reviews

Clone yourself to take over the environment in this bacterial evolution roguelite. Choose mutations and abilities each time you multiply. Use swarm mode to direct your species to attack enemies. Unlock abilities and perks to improve your odds. Compete against other multiplying and evolving species. The environment will change as species evolve or go extinct. Start with one lifeform at the s… If you enjoyed this game, see our list of games similar to Lifeforms: Binary Fission.

Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

82%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:monetization, grinding

82% User Score Based on 860 reviews

Merge towers, defend your base, ascend the throne and battle the horde! If you enjoyed this game, see our list of games similar to Castle Fusion Idle Clicker.

57%Game Brain Score

Most mentioned positive aspects:gameplay, emotional

Most mentioned negative aspects:monetization, music

57% User Score Based on 860 reviews

Killer Sudoku, 2020 brain training puzzle games from Oakever Games If you enjoyed this game, see our list of games similar to Killer Sudoku - Sudoku Puzzles.

73%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:monetization, stability

73% User Score Based on 1,015 reviews

Defend the towers and upgrade your army for war in the epic military strategy! If you enjoyed this game, see our list of games similar to Bunker Wars: WW1 RTS Game.

Hexual Deflection is a minimalistic Multiplayer Arena RTS where you do not only defend against enemy units with towers but also send your own units onto enemy towers. Your goal is to be last player alive on the board. Fast paced and chaotic gameplay may require you to quickly adapt to changes on the playfield To do so, you have only 3 types of buildings which you can place in your claimed area: … If you enjoyed this game, see our list of games similar to Hexual Deflection.

Fight off your body's invaders using the combined strengths of your immune system's defenders! Immunity Wars is a turn-based tactics, classic hex grid, strategy game. Wield your units together effectively to fight off all kinds of bacteria, viruses, and even your own corrupted cells.Classic Hex Grid TacticsImmunity Wars is a classic hex grid tactical experience. You'll use each battlefield's terra… If you enjoyed this game, see our list of games similar to Immunity Wars.

72%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:grinding, replayability

72% User Score Based on 71 reviews

Step into the eerie world of Creeping Dusk, a tower defense game that blends strategic base-building and intense battles against waves of undead. Your task is to build a small town around an abandoned gold mine and defend against monsters that swarm the area. Plan your next move during the day, explore surrounding area, expand the town, fortify your defenses and prepare for the increasingly challe… If you enjoyed this game, see our list of games similar to Creeping Dusk.

61%Game Brain Score

Most mentioned negative aspects:gameplay, monetization

86% User Score Based on 22 reviews

The world keeps changing. Unfortunately, not all things work out for the best. Some animals are endangered. As a driver, you will help transport these innocent creatures to be rescued from poaching. You will meet all kinds of species: rhinos, zebras, oxen that need a new home. Be careful how you drive, they are sensitive to it because they are wild. In this way you will also contribute to saving t… If you enjoyed this game, see our list of games similar to Wild Animals Transporter.

57%Game Brain Score

Most mentioned positive aspects:humor

Most mentioned negative aspects:graphics, story

66% User Score Based on 38 reviews

The School Bus Driver Simulator game offers you the chance to contribute to our future, namely, to transport the children to school. If you enjoyed this game, see our list of games similar to School Bus Driver Simulator.

61%Game Brain Score

Most mentioned positive aspects:graphics, music

Most mentioned negative aspects:gameplay, story

63% User Score Based on 48 reviews

Help protect the core of cyberspace from mutant viruses in this innovative tower defense game packed with roguelite elements! Will you be able to build the ultimate line of defense? If you enjoyed this game, see our list of games similar to CyberTD.

75%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, music

75% User Score Based on 478 reviews

Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy. If you enjoyed this game, see our list of games similar to Defend Your Life: TD.

66%Game Brain Score

Most mentioned positive aspects:story, music

Most mentioned negative aspects:gameplay, grinding

66% User Score Based on 64 reviews

We're happy to present a new game in the Alien Shooter universe! Get prepared to unique tactical gameplay, lots of monster types and 8 fighter types allowing you create your own style of completing missions and defeating bosses. If you enjoyed this game, see our list of games similar to Alien Hallway 2.

75%Game Brain Score

Most mentioned positive aspects:gameplay

Most mentioned negative aspects:graphics, story

75% User Score Based on 152 reviews

Take the fight to the alien homeworld and unleash a massive arsenal of weaponry. Get up close and personal on the battlefield in your power armor to execute devastating attacks and support your defences. If you enjoyed this game, see our list of games similar to Sentinel 3: Homeworld.

35%Game Brain Score

Most mentioned positive aspects:music, story

60% User Score Based on 10 reviews

Look through a microscope and discover a small world made of ever expanding cells of 3 colors. Launch a cell against one of the same color to make them both disappear. Launch it against a cell of a different color and a new cell of the third color will be created. But beware! Cells are aging and become sick and dark. They might spread out and contaminate the whole system. Create white cells to hel… If you enjoyed this game, see our list of games similar to Little Cells.

91%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story

91% User Score Based on 70 reviews

Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time! If you enjoyed this game, see our list of games similar to Life on the Edge.

59%Game Brain Score

Most mentioned positive aspects:humor

Most mentioned negative aspects:graphics, gameplay

59% User Score Based on 73 reviews

Hardcore 2D game with a fascinating and unusual mechanics, where you have to defend the base from annoying saboteurs. If you enjoyed this game, see our list of games similar to Cannons-Defenders: Steam Edition.

43%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

58% User Score Based on 24 reviews

Dear passengers, please take the seats provided. Does that sound familiar? Try what it's like to be a real bus driver. If you enjoyed this game, see our list of games similar to City Bus Driver Simulator.

63%Game Brain Score

Most mentioned positive aspects:graphics

Most mentioned negative aspects:gameplay, story

63% User Score Based on 98 reviews

Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. If you enjoyed this game, see our list of games similar to Infectious.

71%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:replayability, stability

71% User Score Based on 364 reviews

Critic Score 70%Based on 2 reviews

Squeeze into your toga and slide on your sandals to rally the angry mobs of Okhlos and bring down the oppressive god of mythological Greece! If you enjoyed this game, see our list of games similar to Okhlos: Omega.

44%Game Brain Score

Most mentioned negative aspects:stability, gameplay

53% User Score Based on 34 reviews

Our games you might like About the Game You left alone camping in the mountains ... But during this time a virus has invaded the country and a cubic horde is heading towards you! Arm yourself and overcome waves of enemies. Fill up with arms and ammunition between each wave. How much cubic wave can you eliminate? Features : ■ 2 maps! ■ More than 30 levels! ■ 5 different weapons! ■ Shop sys… If you enjoyed this game, see our list of games similar to Cube Defense.

86%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

86% User Score Based on 109 reviews

Build a powerful wall, extract resources, building defenses to survive! If you enjoyed this game, see our list of games similar to North Kingdom: Siege Castle.

32%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:music, story

32% User Score Based on 276 reviews

An insane hybrid of a tower defense game and a procedural music toy with tons of bullets (and healthy number of Wu-Tang references and credit crunch satire). The hit game for iOS now available on Windows and Mac! You are a budding entrepreneur, whose hotel is rather unfortunately located within the territory of Tarnation Tadstock, the Texas Tyrant. Your only defense against Tadstock’s army of sea… If you enjoyed this game, see our list of games similar to Bad Hotel.

Bacteria Buster is a lighthearted cleanup game set inside a lively petri dish. Bacteria continuously emerge from random positions, and your job is to move the mouse, bring down the swatter, and complete each stage’s objective before contamination reaches its limit. The controls are immediate and easy to understand, but rising bacterial health and increasing spawn pressure will gradually make upgra… If you enjoyed this game, see our list of games similar to Bacteria Buster.

Immunity is a fast-paced survival game where your body becomes the battlefield. Play as different immune cells, each with their own strengths, abilities, and playstyles, as you fight through waves of bacteria, viruses, and other threats. Every run pushes you to adapt, choose new mutations, and build a stronger defense before the infection overwhelms the organ you are trying to protect. As you su… If you enjoyed this game, see our list of games similar to Immunity.

A tower defense game with loads of towers and lots of interactions!Machinery Defense is a 2D top-down tower defense game with over 30 towers, 20 enemies, and 20 maps planned for the full release! Defend your base (which also shoots) from an onslaught of various enemy bots, each with their own strengths and weaknesses! Overclock Your TowersPlan strategically on what towers to place and when to Ove… If you enjoyed this game, see our list of games similar to Machinery Defense.

Cellula is a cell biology simulator disguised as a strategy game. Manage a colony of living cells. Build membranes from individual phospholipid bricks, place organelles, import nutrients, fight viruses, detect cancer, and divide your cells to grow. No tutorials. No lectures. Learn real biology by keeping your cells alive. WHAT YOU'LL DOStart with a single cell: a ring of phospholipid bricks tha… If you enjoyed this game, see our list of games similar to Cellula.

VOID ARMOR: FORM DRIVE is a top-down mecha action shooter focused on fast missions, weapon switching, and performance-based ranks. Take control of the experimental unit “ARORA” and challenge missions against enemy machines. Close the distance and strike with the Energy Blade, attack from range with the rifle or launcher, and use the defense system to withstand incoming attacks. Choosing the right… If you enjoyed this game, see our list of games similar to VOID ARMOR: FORM DRIVE.

(Demo releasing June 14, 2026) Blightsilver is a story-rich deckbuilder card game featuring story-rich supernatural urban dark fantasy visual novel. The story will follows ordinary university students who get dragged into the hidden supernatural layer of the city, where they must fight using mysterious cards. The card battle system of Blightsilver is a unique guess-and-hit opponent's hidden ce… If you enjoyed this game, see our list of games similar to Blightsilver.