Games like CRISPR Defense

Take control of the body’s defense system in this fast-paced action shooter. Step into the role of a powerful immune cell and use precise touch controls to target and eliminate waves of invading bacteria and viruses. If you enjoyed this game, see our list of games similar to BODYguard: CellWars.

61%Game Brain Score

Most mentioned positive aspects:music, story

100% User Score Based on 12 reviews

Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

Take control of a living virus and infect the human body from within. Destroy cells, harvest Biomass, evolve powerful mutations, and defend your Viral Core against relentless immune-system attacks in this incremental tower defense game. If you enjoyed this game, see our list of games similar to How to Turn Zombie.

Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

# BIOFIGHTERS [Watch the BIOFIGHTERS Trailer on YouTube]( ) ## Overview **BIOFIGHTERS** is an action-packed educational game that immerses players in the world of the immune system. Players take control of different immune cells, each with unique roles, to defend the body against increasingly dangerous pathogens. The game is structured into two mini-games and one larger level, forming a co… If you enjoyed this game, see our list of games similar to BIOFIGHTERS.

Typo! is an arcade typing defense game where your keyboard is the last line of defense. Word-based viruses are attacking your system. Type their prompts before they breach your firewall, keep your mistakes under control, and survive as the pressure keeps rising. Every run is built around speed, accuracy, target priority, and staying calm when the screen starts to close in. Type To Survive E… If you enjoyed this game, see our list of games similar to Typo!.

Jagoan N3on presentsControlling the immune system forces with unique abilities, and defending the lungs from deadly threats in a battle for human health. It's a unique and exciting gaming experience to safeguard the lungs from virus attacks and support the goals of Health and Well-being in the Sustainable Development Agenda. In this game, there will be two modes: Hack and Slash, as well as Tower … If you enjoyed this game, see our list of games similar to Lung Defender: The Tuberculosis Battle.

Just as the COVID-19 pandemic is starting to sweep through the world, Antidote Laboratories receives a strange package. You are assigned to study it and WHAM!, get thrown into the frontlines of medical science. Based on real events and loaded with useful facts about COVID-19, the Antidote COVID-19 takes you on a science adventure! • Defend the stem cell against viruses and bacteria • Build your o… If you enjoyed this game, see our list of games similar to Antidote COVID-19.

"Inoculation: Defend the Body" is an immersive tower defense game set within the intricate landscape of the human body. Players embark on a crucial mission to protect the body from relentless waves of invading pathogens seeking to cause chaos and illness. The game unfolds within the intricately designed environments representing vital organs, bloodstream passages, and cellular structures. Each … If you enjoyed this game, see our list of games similar to Inoculation.

English:Hey you! ViralAttack is a game where you have to control the immune system to defend the healthy cells from the attacking viruses. After every wave of viruses you have the possibility to buy new defender-cells with upgrades in Range, Hitrate, Speed and Damage.  Therefore you use points, which you receive ingame for defending your healthy cells. If a virus infects an healty cell, the infect… If you enjoyed this game, see our list of games similar to ViralAttack.

We decided to make the alpha free for anyone to download!  Please join our Discord here if you want to give some feedback or require any support! GAMEPLAY VIDEO - this will help you get started QUICK START GUIDE - ALPHA  The current build can be a little bit overwhelming because it's a pure sandbox experience in which you are on your own to understand the mechanics, we're currently working on a … If you enjoyed this game, see our list of games similar to Lifecraft.

45%Game Brain Score

Most mentioned negative aspects:gameplay

69% User Score Based on 16 reviews

Your Human is sick and it's up to you, a naive T Cell, to solve puzzles, fight off bacteria and viruses, and learn about the immune system. Make your human healthy again in this dungeon crawler adventure! If you enjoyed this game, see our list of games similar to Your Human is Sick.

63%Game Brain Score

Most mentioned positive aspects:gameplay, monetization

Most mentioned negative aspects:stability, music

63% User Score Based on 303 reviews

Take the Field. Command the Offense. Forge Your Football Legacy. If you enjoyed this game, see our list of games similar to Ultimate QB: Football Legend.

A tower defense game supporting up to 4 players online, with various equipment to boost your power. If you enjoyed this game, see our list of games similar to 保卫实验室 (Defend the Lab).

Build defenses on randomly generated archipelagos and fend off waves of pirates! Expand land plots, combine defense towers, and collect treasures to strengthen your islands. Guard your treasures and become the wealthiest lord! If you enjoyed this game, see our list of games similar to Treasure's Mine!.

51%Game Brain Score

Most mentioned negative aspects:gameplay, grinding

67% User Score Based on 27 reviews

Clone yourself to take over the environment in this bacterial evolution roguelite. Choose mutations and abilities each time you multiply. Use swarm mode to direct your species to attack enemies. Unlock abilities and perks to improve your odds. Compete against other multiplying and evolving species. The environment will change as species evolve or go extinct. Start with one lifeform at the s… If you enjoyed this game, see our list of games similar to Lifeforms: Binary Fission.

Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

82%Game Brain Score

Most mentioned positive aspects:story, gameplay

Most mentioned negative aspects:monetization, grinding

82% User Score Based on 860 reviews

Merge towers, defend your base, ascend the throne and battle the horde! If you enjoyed this game, see our list of games similar to Castle Fusion Idle Clicker.

73%Game Brain Score

Most mentioned positive aspects:graphics, gameplay

Most mentioned negative aspects:monetization, stability

73% User Score Based on 1,015 reviews

Defend the towers and upgrade your army for war in the epic military strategy! If you enjoyed this game, see our list of games similar to Bunker Wars: WW1 RTS Game.

Fight off your body's invaders using the combined strengths of your immune system's defenders! Immunity Wars is a turn-based tactics, classic hex grid, strategy game. Wield your units together effectively to fight off all kinds of bacteria, viruses, and even your own corrupted cells.Classic Hex Grid TacticsImmunity Wars is a classic hex grid tactical experience. You'll use each battlefield's terra… If you enjoyed this game, see our list of games similar to Immunity Wars.

72%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:grinding, replayability

72% User Score Based on 71 reviews

Step into the eerie world of Creeping Dusk, a tower defense game that blends strategic base-building and intense battles against waves of undead. Your task is to build a small town around an abandoned gold mine and defend against monsters that swarm the area. Plan your next move during the day, explore surrounding area, expand the town, fortify your defenses and prepare for the increasingly challe… If you enjoyed this game, see our list of games similar to Creeping Dusk.

57%Game Brain Score

Most mentioned positive aspects:humor

Most mentioned negative aspects:graphics, story

66% User Score Based on 38 reviews

The School Bus Driver Simulator game offers you the chance to contribute to our future, namely, to transport the children to school. If you enjoyed this game, see our list of games similar to School Bus Driver Simulator.

75%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:grinding, music

75% User Score Based on 478 reviews

Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy. If you enjoyed this game, see our list of games similar to Defend Your Life: TD.

66%Game Brain Score

Most mentioned positive aspects:story, music

Most mentioned negative aspects:gameplay, grinding

66% User Score Based on 64 reviews

We're happy to present a new game in the Alien Shooter universe! Get prepared to unique tactical gameplay, lots of monster types and 8 fighter types allowing you create your own style of completing missions and defeating bosses. If you enjoyed this game, see our list of games similar to Alien Hallway 2.

35%Game Brain Score

Most mentioned positive aspects:music, story

60% User Score Based on 10 reviews

Look through a microscope and discover a small world made of ever expanding cells of 3 colors. Launch a cell against one of the same color to make them both disappear. Launch it against a cell of a different color and a new cell of the third color will be created. But beware! Cells are aging and become sick and dark. They might spread out and contaminate the whole system. Create white cells to hel… If you enjoyed this game, see our list of games similar to Little Cells.

91%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:story

91% User Score Based on 70 reviews

Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time! If you enjoyed this game, see our list of games similar to Life on the Edge.

59%Game Brain Score

Most mentioned positive aspects:humor

Most mentioned negative aspects:graphics, gameplay

59% User Score Based on 73 reviews

Hardcore 2D game with a fascinating and unusual mechanics, where you have to defend the base from annoying saboteurs. If you enjoyed this game, see our list of games similar to Cannons-Defenders: Steam Edition.

43%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

58% User Score Based on 24 reviews

Dear passengers, please take the seats provided. Does that sound familiar? Try what it's like to be a real bus driver. If you enjoyed this game, see our list of games similar to City Bus Driver Simulator.

63%Game Brain Score

Most mentioned positive aspects:graphics

Most mentioned negative aspects:gameplay, story

63% User Score Based on 98 reviews

Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. If you enjoyed this game, see our list of games similar to Infectious.

71%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:replayability, stability

71% User Score Based on 364 reviews

Critic Score 70%Based on 2 reviews

Squeeze into your toga and slide on your sandals to rally the angry mobs of Okhlos and bring down the oppressive god of mythological Greece! If you enjoyed this game, see our list of games similar to Okhlos: Omega.

40%Game Brain Score

Most mentioned positive aspects:replayability

Most mentioned negative aspects:graphics, story

57% User Score Based on 21 reviews

Conflict Craft 2 it's a strategy game where you'll need proper management of your resources, but also leadership skills in order to fully control the opposing forces. If you enjoyed this game, see our list of games similar to ConflictCraft 2.

32%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:music, story

32% User Score Based on 276 reviews

An insane hybrid of a tower defense game and a procedural music toy with tons of bullets (and healthy number of Wu-Tang references and credit crunch satire). The hit game for iOS now available on Windows and Mac! You are a budding entrepreneur, whose hotel is rather unfortunately located within the territory of Tarnation Tadstock, the Texas Tyrant. Your only defense against Tadstock’s army of sea… If you enjoyed this game, see our list of games similar to Bad Hotel.

82%Game Brain Score

Most mentioned positive aspects:gameplay, graphics

Most mentioned negative aspects:stability, character development

95% User Score Based on 38 reviews

Tower of Spirit is a fast turn-based RPG where your choices matter. Gather a group of unique characters, survive a serie of random encounters and battle your way to reach the enigmatic tower! If you enjoyed this game, see our list of games similar to Tower of Spirit.

55%Game Brain Score

Most mentioned positive aspects:gameplay, music

Most mentioned negative aspects:graphics, grinding

55% User Score Based on 102 reviews

Take control of a determined White Blood Cell on a quest for self discovery, vengeance, punishment and annihilation of all evil germs who would dare infiltrate an unsuspecting and innocent human body in this unique and organic experience. Battle evil germs by slamming into them, using your Powerbutt ability to further enhance the damage and pain inflicted. If you enjoyed this game, see our list of games similar to Germ Wars.

Command the immune system in an incremental auto-battler with a touch of roguelite. Build your army of cells, pick upgrades and defend six organs from real viruses, bacteria, fungi and parasites — from the gut to the brain. If you enjoyed this game, see our list of games similar to Save Your Body!.

This is an 18 ban tower defense game. The game controls the movement of the protagonist through the arrow keys on the keyboard or the left mouse button, and interacts with characters and objects in the scene through the space bar. If you enjoyed this game, see our list of games similar to Death row inmates on the run.

A tower defense game with loads of towers and lots of interactions!Machinery Defense is a 2D top-down tower defense game with over 30 towers, 20 enemies, and 20 maps planned for the full release! Defend your base (which also shoots) from an onslaught of various enemy bots, each with their own strengths and weaknesses! Overclock Your TowersPlan strategically on what towers to place and when to Ove… If you enjoyed this game, see our list of games similar to Machinery Defense.

The match is only half the job. Build a squad that fits the way you want to play, keep the dressing room together and make the right calls when matchday arrives. Egos, rivalries and loyalties can make or break your season. If you enjoyed this game, see our list of games similar to Offside Deal: Football At Any Cost.

Cells of Division is a top-down bullet hell roguelike. Fight with past-run clones (up to 6 allies), mix ~100 items, and defeat 50+ bosses. Destroy viruses and defend the immune system! If you enjoyed this game, see our list of games similar to Cells of Division.

Ever wanted to have zombies, many zombies, and see them infect the world? Well, then let's go farming dead! Farm zombies for fun and profit in this relaxing idle simulation game! Start from the bottom with a cute zombie and with big dreams of achieving zombie domination. Tap n' swipe to collect viruses, spawn zombies, buy upgrades and repeat. It's simple as that. There are many hilarious zombies … If you enjoyed this game, see our list of games similar to Farming Dead - Idle Zombies.

Lead an ever-evolving cosmic virus in this action roguelite: infect, fuse your cell into new shapes, choose your abilities, ascend without limit and conquer entire planets. If you enjoyed this game, see our list of games similar to Alpha Genesis.

Draw The Defense is an innovative defense game that deeply integrates "real-time drawing" with "strategic defense." Unlike traditional tower defense games that rely on fixed buildings, this game completely returns the power of defense to the player—you are not placing defensive units, but rather "drawing the defensive line" by hand during the battle, instantly changing the enemy's movement path an… If you enjoyed this game, see our list of games similar to Draw The Defense.

Get the # 1 tower defense game! "Color Defense" is the ultimate game for both casual players and strategy action fans! A unique gaming experience and all content is completely free to play! "Color Defense" has been optimized for all new devices, supports the latest operating system as well as iPad and iPhone and the new iPhoneX. The game is the ideal companion as it has no entry barriers and is … If you enjoyed this game, see our list of games similar to Color Defense – Epic TD Game.

  STATIC You are a Spark — the last line of defense on a dying circuit board.                                                                                                                                                                                 Corrupted data nodes swarm toward your core. Your only weapon is the electrical field surrounding you: everything inside it takes damage, but… If you enjoyed this game, see our list of games similar to STATIC.

CELL WARFARE - A Micro RTS Game Cell Warfare is a fast-paced 2D real-time strategy game created for Trijam #354 (3-hour game jam).  The theme was "Cell Wars" - and this game takes it literally! STORY: You control a healthy cell defending against a viral invasion. Command your immune system and  fight back against the virus trying to take over! GAMEPLAY: Battle against an AI opponent in this… If you enjoyed this game, see our list of games similar to Cell Warfare.

Charming retro action arcade shooter with roguelite elements (and a pet space worm!).     The dastardly humans have achieved interstellar spaceflight once more and are spreading throughout the galaxy like a virus. The call has gone out: it is time to send them back to the Stone Age once again, for the good of all alienkind. Regrettably, the council has ignored the human threat and left the … If you enjoyed this game, see our list of games similar to Space Force Bargain Bin.

Sci-fi tower defense meets ARPG-like hero combat. Build towers then fight alongside them with your hero as you battle through a campaign to uncover the fate of a colonization effort on a distant planet. If you enjoyed this game, see our list of games similar to Decimation.

We've traveled to the past to conquer these fertile lands. Now, you must defend them from the blood cult intent on taking it for themselves. Be careful though: from where their blood is spilled, ancient magicks empower whomever is still alive. If you enjoyed this game, see our list of games similar to Bloodtide Tower Defense.

Dragonfall,  tower-defense project is a Unity-based experience where players place up to twenty-five defenders on procedurally generated 3D terrain while fending off waves of dragon enemies. The underlying systems Enemy Spawner, Wave Progression System, and Player Performance Tracker collaborate to create adaptive encounters: each wave’s size, composition, and pace shift according to player perfor… If you enjoyed this game, see our list of games similar to DragonFall.

Build a colony from scratch, set up production chains, and defend against raids. Manage resources, research technologies, expand your settlement, and survive each escalating wave! If you enjoyed this game, see our list of games similar to Pinevale Settlements.