Skip to main content
Games like CRISPR Defense

Games like CRISPR Defense

Games like CRISPR Defense

Looking for games like CRISPR Defense? Here are top action recommendations, selected from player-similarity data — start with Germ Wars, BODYguard: CellWars or Listeria Wars.

Change display type

Skip Platform filter

Skip Play Mode filter

Skip Price filter
  1. View Game
    55%Game Brain Score
    Most mentioned positive aspects:gameplay, music
    Most mentioned negative aspects:graphics, grinding
    55% User Score Based on 102 reviews

    Take control of a determined White Blood Cell on a quest for self discovery, vengeance, punishment and annihilation of all evil germs who would dare infiltrate an unsuspecting and innocent human body in this unique and organic experience. Battle evil germs by slamming into them, using your Powerbutt ability to further enhance the damage and pain inflicted. If you enjoyed this game, see our list of games similar to Germ Wars.

    View Game
  2. Take control of the body’s defense system in this fast-paced action shooter. Step into the role of a powerful immune cell and use precise touch controls to target and eliminate waves of invading bacteria and viruses. If you enjoyed this game, see our list of games similar to BODYguard: CellWars.

    View Game
  3. 61%Game Brain Score
    Most mentioned positive aspects:music, story
    100% User Score Based on 12 reviews

    Listeria Wars is a tactical strategy where we protect the hero’s body from various infections and viruses by controlling the troops of the immune system. We can observe his personal life and even influence it with side effects. If you enjoyed this game, see our list of games similar to Listeria Wars.

    View Game
  4. 85%Game Brain Score
    Most mentioned positive aspects:story, gameplay
    Most mentioned negative aspects:grinding, character development
    85% User Score Based on 117 reviews

    Years after her hometown was destroyed by an evil group, Haruka joins the company, Public Defense Corp. Now, armed with a bipedal robot, Haruka can work towards getting her revenge for what happened to her home. If you enjoyed this game, see our list of games similar to Public Defense Corp.

    View Game
  5. Mitosis Mercenary - Cell Wars Jam Game Jam Entry for Trijam #354 You are a white blood cell warrior. Defend the body against an endless onslaught of viruses, bacteria, and other pathogens. Grow stronger through mitosis, collect powerful upgrades, and survive the final wave to achieve victory! Can you grow strong enough to survive the final wave? About the Game Mitosis Mercenary is a top-dow… If you enjoyed this game, see our list of games similar to Mitosis Mercenary.

    View Game
  6. In DC3: Viral Menace, you play as Dr. Vidya Vichaar, battling a viral infection ravaging her daughter's body. Zoom through artfully crafted levels themed as pages of a comic book in Vidya's magnificent technological ship - The Caper-5000. Navigate various systems of the human body in this top-down, isometric adventure. Begin in the cavernous respiratory system, descend into the acidic digestive s… If you enjoyed this game, see our list of games similar to DC3: Viral Menace.

    View Game
  7. Bioneers – Game Features Unique gameplay that combines factory-building with organism simulation. Instead of buildings — cells, instead of conveyor belts — vessels, instead of enemies — viruses. The bigger your organism, the more powerful it becomes — but it also needs more resources to sustain itself. Animations inspired by real biology. All cell and system movements are based on behavioral mod… If you enjoyed this game, see our list of games similar to Bioneers.

    View Game
  8. A virus is attacking your cells, and its up to you to defend them! Buy and combine cells to assemble your immune response. Discover powerful synergies to overcome a constantly evolving enemy in this physics-based auto battler. Build an ironclad immune defense in 10 turns or perish.Create the ultimate immune response Create the ultimate immune response: Combine immune cells in interesting ways to o… If you enjoyed this game, see our list of games similar to Auto Immune.

    View Game
  9. # BIOFIGHTERS [Watch the BIOFIGHTERS Trailer on YouTube]( ) ## Overview **BIOFIGHTERS** is an action-packed educational game that immerses players in the world of the immune system. Players take control of different immune cells, each with unique roles, to defend the body against increasingly dangerous pathogens. The game is structured into two mini-games and one larger level, forming a co… If you enjoyed this game, see our list of games similar to BIOFIGHTERS.

    View Game
  10. 50%Game Brain Score
    50% User Score Based on 1 reviews

    Jagoan N3on presentsControlling the immune system forces with unique abilities, and defending the lungs from deadly threats in a battle for human health. It's a unique and exciting gaming experience to safeguard the lungs from virus attacks and support the goals of Health and Well-being in the Sustainable Development Agenda. In this game, there will be two modes: Hack and Slash, as well as Tower … If you enjoyed this game, see our list of games similar to Lung Defender: The Tuberculosis Battle.

    View Game
  11. 49%Game Brain Score
    49% User Score Based on 6 reviews

    Just as the COVID-19 pandemic is starting to sweep through the world, Antidote Laboratories receives a strange package. You are assigned to study it and WHAM!, get thrown into the frontlines of medical science. Based on real events and loaded with useful facts about COVID-19, the Antidote COVID-19 takes you on a science adventure! • Defend the stem cell against viruses and bacteria • Build your o… If you enjoyed this game, see our list of games similar to Antidote COVID-19.

    View Game
  12. "Inoculation: Defend the Body" is an immersive tower defense game set within the intricate landscape of the human body. Players embark on a crucial mission to protect the body from relentless waves of invading pathogens seeking to cause chaos and illness. The game unfolds within the intricately designed environments representing vital organs, bloodstream passages, and cellular structures. Each … If you enjoyed this game, see our list of games similar to Inoculation.

    View Game
  13. English:Hey you! ViralAttack is a game where you have to control the immune system to defend the healthy cells from the attacking viruses. After every wave of viruses you have the possibility to buy new defender-cells with upgrades in Range, Hitrate, Speed and Damage.  Therefore you use points, which you receive ingame for defending your healthy cells. If a virus infects an healty cell, the infect… If you enjoyed this game, see our list of games similar to ViralAttack.

    View Game
  14. 45%Game Brain Score
    Most mentioned negative aspects:gameplay
    69% User Score Based on 16 reviews

    Your Human is sick and it's up to you, a naive T Cell, to solve puzzles, fight off bacteria and viruses, and learn about the immune system. Make your human healthy again in this dungeon crawler adventure! If you enjoyed this game, see our list of games similar to Your Human is Sick.

    View Game
  15. Welcome to the Human Immunity Command Center�� As a new commander, you must command cells to attack, defeat invading bacteria and viruses, and defend body cells. Be careful! Some immune cells could be too powerful to kill everything, including our original cells! Here, you can produce different immune cells, deploy your resistant cell line of defense, learn how bacteria and viruses damage human ce… If you enjoyed this game, see our list of games similar to 战地细胞(Battlefield Cell).

    View Game
  16. Defend the body in vaXinator, a fast-paced action roguelike! As the last white blood cell, unleash powerful abilities and antibodies to fight off waves of infections. Test your reflexes in this microscopic battle for survival. How long can you hold the line? If you enjoyed this game, see our list of games similar to vaXinator.

    View Game
  17. Command your virus to invade cells, wage an all-out war against the immune system, and conquer the world. Cell Battlefield Cells are the primary battlegrounds of the game. You need to command your virus to enter host cells and utilize the replication mechanisms within the cell nucleus to rapidly reproduce. As the virus multiplies, the host cell's apoptosis signaling pathway will gradually be act… If you enjoyed this game, see our list of games similar to Propa..

    View Game
  18. View Game
  19. 66%Game Brain Score
    Most mentioned positive aspects:gameplay
    Most mentioned negative aspects:music, story
    76% User Score Based on 38 reviews

    Stronghold Defenders is a Tower Defense game with a twist. Unlike normal Tower Defense games, you have gathering units and resources to manage as well as your defending units that are used to attack enemies.  This adds another strategy layer to the game where you have to make decisions every turn on what resources you want to gather and if you want to recruit a defender or a gatherer.  You also ne… If you enjoyed this game, see our list of games similar to Stronghold Defenders.

    View Game
  20. 61%Game Brain Score
    Most mentioned positive aspects:graphics, music
    Most mentioned negative aspects:gameplay, story
    63% User Score Based on 48 reviews

    Help protect the core of cyberspace from mutant viruses in this innovative tower defense game packed with roguelite elements! Will you be able to build the ultimate line of defense? If you enjoyed this game, see our list of games similar to CyberTD.

    View Game
  21. View Game
    View Game
  22. View Game
  23. View Game
    92%Game Brain Score
    Most mentioned positive aspects:story, gameplay
    Most mentioned negative aspects:music, stability
    92% User Score Based on 71 reviews

    Arcus is a fantasy action game where failure is just the next step in the story. Use a bow to aim and fire arrows at invading enemies. Swing your sword at any angle to get past enemy defenses. Spend resources between missions to buy special arrow types and increase your chances of success while you solve the mystery behind the new undead skeleton faction in a land where magic has been made taboo. If you enjoyed this game, see our list of games similar to Arcus.

    View Game
  24. 75%Game Brain Score
    Most mentioned positive aspects:gameplay, graphics
    Most mentioned negative aspects:grinding, music
    75% User Score Based on 478 reviews

    Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy. If you enjoyed this game, see our list of games similar to Defend Your Life: TD.

    View Game
  25. 75%Game Brain Score
    Most mentioned positive aspects:gameplay
    Most mentioned negative aspects:graphics, story
    75% User Score Based on 152 reviews

    Take the fight to the alien homeworld and unleash a massive arsenal of weaponry. Get up close and personal on the battlefield in your power armor to execute devastating attacks and support your defences. If you enjoyed this game, see our list of games similar to Sentinel 3: Homeworld.

    View Game
  26. 91%Game Brain Score
    Most mentioned positive aspects:gameplay, graphics
    Most mentioned negative aspects:story
    91% User Score Based on 70 reviews

    Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time! If you enjoyed this game, see our list of games similar to Life on the Edge.

    View Game
  27. 59%Game Brain Score
    Most mentioned positive aspects:humor
    Most mentioned negative aspects:graphics, gameplay
    59% User Score Based on 73 reviews

    Hardcore 2D game with a fascinating and unusual mechanics, where you have to defend the base from annoying saboteurs. If you enjoyed this game, see our list of games similar to Cannons-Defenders: Steam Edition.

    View Game
  28. 43%Game Brain Score
    Most mentioned positive aspects:gameplay, music
    Most mentioned negative aspects:graphics, grinding
    58% User Score Based on 24 reviews

    Dear passengers, please take the seats provided. Does that sound familiar? Try what it's like to be a real bus driver. If you enjoyed this game, see our list of games similar to City Bus Driver Simulator.

    View Game
  29. View Game
    63%Game Brain Score
    Most mentioned positive aspects:graphics
    Most mentioned negative aspects:gameplay, story
    63% User Score Based on 98 reviews

    Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. If you enjoyed this game, see our list of games similar to Infectious.

    View Game
  30. 49%Game Brain Score
    Most mentioned positive aspects:graphics, music
    Most mentioned negative aspects:gameplay, grinding
    79% User Score Based on 14 reviews

    Do you want to live like a coward for a lifetime? Or live like be a hero, even if only for a few minutes? Show your bravery in Bugs Must Die! If you enjoyed this game, see our list of games similar to Bugs Must Die.

    View Game
  31. View Game
    44%Game Brain Score
    Most mentioned negative aspects:stability, gameplay
    53% User Score Based on 34 reviews

    Our games you might like About the Game You left alone camping in the mountains ... But during this time a virus has invaded the country and a cubic horde is heading towards you! Arm yourself and overcome waves of enemies. Fill up with arms and ammunition between each wave. How much cubic wave can you eliminate? Features : ■ 2 maps! ■ More than 30 levels! ■ 5 different weapons! ■ Shop sys… If you enjoyed this game, see our list of games similar to Cube Defense.

    View Game
  32. 86%Game Brain Score
    Most mentioned positive aspects:graphics, gameplay
    86% User Score Based on 109 reviews

    Build a powerful wall, extract resources, building defenses to survive! If you enjoyed this game, see our list of games similar to North Kingdom: Siege Castle.

    View Game
  33. 32%Game Brain Score
    Most mentioned positive aspects:gameplay, graphics
    Most mentioned negative aspects:music, story
    32% User Score Based on 276 reviews

    An insane hybrid of a tower defense game and a procedural music toy with tons of bullets (and healthy number of Wu-Tang references and credit crunch satire). The hit game for iOS now available on Windows and Mac! You are a budding entrepreneur, whose hotel is rather unfortunately located within the territory of Tarnation Tadstock, the Texas Tyrant. Your only defense against Tadstock’s army of sea… If you enjoyed this game, see our list of games similar to Bad Hotel.

    View Game
  34. View Game
  35. Infect. Evolve. Ascend.Alpha Genesis is an action roguelite where you guide a cosmic viral organism through a process of continuous evolution, combat, and transcendence. You control the virus directly: move with WASD, aim and activate abilities with the mouse. Every second requires tactical decisions as you navigate through hordes of immune cells, collect resources, and grow your colony. CORE GA… If you enjoyed this game, see our list of games similar to Alpha Genesis.

    View Game
  36. Draw The Defense is an innovative defense game that deeply integrates "real-time drawing" with "strategic defense." Unlike traditional tower defense games that rely on fixed buildings, this game completely returns the power of defense to the player—you are not placing defensive units, but rather "drawing the defensive line" by hand during the battle, instantly changing the enemy's movement path an… If you enjoyed this game, see our list of games similar to Draw The Defense.

    View Game
  37. 84%Game Brain Score
    84% User Score Based on 1,341 reviews

    Get the # 1 tower defense game! "Color Defense" is the ultimate game for both casual players and strategy action fans! A unique gaming experience and all content is completely free to play! "Color Defense" has been optimized for all new devices, supports the latest operating system as well as iPad and iPhone and the new iPhoneX. The game is the ideal companion as it has no entry barriers and is … If you enjoyed this game, see our list of games similar to Color Defense – Epic TD Game.

    View Game
  38. 31%Game Brain Score
    31% User Score Based on 3 reviews

      STATIC You are a Spark — the last line of defense on a dying circuit board.                                                                                                                                                                                 Corrupted data nodes swarm toward your core. Your only weapon is the electrical field surrounding you: everything inside it takes damage, but… If you enjoyed this game, see our list of games similar to STATIC.

    View Game
  39. Cart Panic! OS is not just a tycoon game. It's a fully functional operating system where you run an online store while hackers attack you, viruses pop up, customers rage in chat, and a high-stakes card game tempts you to gamble your profits away. You start with $50, an ugly desktop, and your first debt. Your store has zero reviews. Your first supplier is already late. Then everything happens at o… If you enjoyed this game, see our list of games similar to Cart Panic! OS - E-Commerce Tycoon.

    View Game
  40. CELL WARFARE - A Micro RTS Game Cell Warfare is a fast-paced 2D real-time strategy game created for Trijam #354 (3-hour game jam).  The theme was "Cell Wars" - and this game takes it literally! STORY: You control a healthy cell defending against a viral invasion. Command your immune system and  fight back against the virus trying to take over! GAMEPLAY: Battle against an AI opponent in this… If you enjoyed this game, see our list of games similar to Cell Warfare.

    View Game
  41. Stadium riots have suddenly turned into chaos! Angry fans, dangerous hooligans, and crazy ultra leaders are flooding onto the field. Set up a defense line consisting of security forces, military units, and special operations teams and stop this football madness! Strategic Placement: Position your heroes tactically on the field Increasing Difficulty: Each wave brings stronger and more crowded… If you enjoyed this game, see our list of games similar to Football Survivors.

    View Game
  42. Charming retro action arcade shooter with roguelite elements (and a pet space worm!).     The dastardly humans have achieved interstellar spaceflight once more and are spreading throughout the galaxy like a virus. The call has gone out: it is time to send them back to the Stone Age once again, for the good of all alienkind. Regrettably, the council has ignored the human threat and left the … If you enjoyed this game, see our list of games similar to Space Force Bargain Bin.

    View Game
  43. Dragonfall,  tower-defense project is a Unity-based experience where players place up to twenty-five defenders on procedurally generated 3D terrain while fending off waves of dragon enemies. The underlying systems Enemy Spawner, Wave Progression System, and Player Performance Tracker collaborate to create adaptive encounters: each wave’s size, composition, and pace shift according to player perfor… If you enjoyed this game, see our list of games similar to DragonFall.

    View Game
  44. Pinevale Settlements is a colony-building simulator that blends production and defense. Start small, gather resources, construct buildings, automate production, research technologies, and keep your colony alive against ever-stronger raids. Coming in full release:- Build – Defend – Expand   - Create production chains from gatherers to workshops   - Defend against raids with walls, towers, and pa… If you enjoyed this game, see our list of games similar to Pinevale Settlements.

    View Game
  45. Race Max Pro is a fast, stylish arcade racing game that blends Street, Drift, and Drag into one skill-driven experience. Dominate short, high-intensity races with tight controls, deep tuning, and a garage full of real licensed cars. Three Ways to RaceMaster three distinct racing styles. Street tests your control and racecraft, Drift rewards precision and flow, Drag demands perfect timin… If you enjoyed this game, see our list of games similar to Race Max Pro.

    View Game
  46. Collector's Edition Luft Gears is a dieselpunk space simulation originally built for the Game Boy! Now fully playable on Steam. This faithful port preserves every pixel, sound, and moment from the original cartridge, while adding modern comforts for PC players. Take command of your ship as a veteran pilot sent to investigate a mysterious distress signal from deep space. Manage your systems, ma… If you enjoyed this game, see our list of games similar to Luft Gears.

    View Game
  47. DEFEND. COLLECT. REDACTED. REPEAT.Atlas Station is under constant asteroid bombardment. You're the latest Station Manager sent to keep the operation running—and you will fail. The question is how much progress you'll make before the station shuts you out and you're terminated. MASTER THE DEBRIS FIELDStand your ground against the endless onslaught of the debris field cascading around Atlas. … If you enjoyed this game, see our list of games similar to The Atlas Problem.

    View Game
  48. 50%Game Brain Score
    50% User Score Based on 1 reviews

    a fun tower defense game where you fight enemies, buy upgrades, unlock achievements and collect powerful allies along the way.  DISCLAIMER This is still in development, meaning that this project is in a subject to change, if you got any recommendations on what you want to see for this game, leave it in comments down bellow. Thank you very much for playing! :) MAIN STORY A fellow travele… If you enjoyed this game, see our list of games similar to Battlers battle against the infection.

    View Game
  49. Defend your computer from incoming viruses using powerful turrets! Tower Defense for Virus is a tower defense game with rogue-lite elements. Strategically place your turrets to quickly eliminate waves of viruses and protect your system from the ever-growing threat. The stage is set inside a PC! Viruses of all kinds are advancing from different directions toward the system. From regular virus… If you enjoyed this game, see our list of games similar to Tower defense for virus.

    View Game
  50. Modular OrganismsIn Evoscape, the player and each enemy is made out of cells. If all cells are destroyed, an organism dies. Have highly specialized or more generalist cells, by picking specific genes for them. Become a slow moving powerhouse, by dividing your valuable cells a lot, protect your strong cells by building a defensive cell wall around them or stay small, agile and versitile. The strat… If you enjoyed this game, see our list of games similar to Evoscape.

    View Game