In Manhunt 2, Daniel Lamb, a former subject of a failed secret research project, escapes an asylum with the help of an alter ego, Leo Kasper, after regaining consciousness with no memory of his past. Together, they evade the Pickman Project, a group determined to eliminate them and suppress the truth, while trying to uncover Daniel's past and the reasons behind the experiment. The game is a stealth-based survival horror experience with gruesome takes on melee combat.