Games like Serum

"P.A.M.E.L.A. is a single-player, open-world horror game set in the decaying utopian city of Eden. As a Sleeper, scavenge for resources, build and upgrade equipment, and navigate relationships with various factions to survive. Experience a dense atmosphere, stunning graphics, and a good plot, but be prepared for numerous bugs, grinding, and subpar optimization."

"Nightingale" is a PVE open-world survival crafting Role Playing Game that can be played offline or with up to 2 players in co-op mode. The game features excellent gameplay, awesome visuals, and a wholesome story set in a variety of mystical and dangerous realms, where players must build, craft, fight, and explore to become skilled Realmwalkers and find their way to the magical city of Nightingale. Despite some bugs and grinding, the game is very atmospheric and offers ingenious replayability.

"Wild West Dynasty" is a simulation game that allows players to build and manage their own town in the American Frontier. Gather resources, establish businesses, and make decisions to ensure the prosperity and survival of your settlers. Experience various challenges, natural disasters, and encounters with outlaws in this immersive wild west setting.

Towers of Aghasba, an open-world experience where players can build vast settlements and grow sprawling ecosystems on their fantasy island.

"Population Zero" is a Sci-Fi RPG with a focus on survival and exploration in a vast, mysterious world. Offering both PvE and PvP gameplay, players can choose to cooperate with others or compete for resources and supremacy. With impressive visuals, a haunting soundtrack, and a high level of grinding, the game is a mix of beauty, danger, and bugs, catering to both newcomers and hardcore players alike.

"Novus Inceptio" is a sandbox survival game set in a procedurally generated world. Players must gather resources, craft tools, and build shelters to survive against harsh environments and hostile creatures. With a focus on player freedom, the game offers various activities such as farming, hunting, and building, providing an immersive experience in a persistent world.

Survive, exploring a vast island where everything is interactive and covered with zombies. - Build and upgrade bases using materials obtained by cutting down trees, mining up stones and collecting artifacts. - Get food through hunting and farming, cook and eat. - Build fortresses and traps to guide zombie movements to defend the flocking zombie waves. - Collect various items, weapons and costumes …

"Goblin Stone" is a turn-based roguelite where you lead a party of goblins in their quest for survival against human adventurers. Customize your party with different classes, abilities, and genetics, and experience a unique combat system where positioning determines the order of actions. Manage a thriving goblin colony, build your lair, and breed your goblins to create the perfect party. The game features nostalgic storybook-inspired visuals and an epic soundtrack composed by Peter McConnell.

"Mirthwood is a single-player open-world RPG life sim with grinding elements, where you manage a homestead, craft items, and trade with towns. Experience an immersive medieval fantasy world with hand-drawn graphics, real-time combat, and survival-lite features. Battle various enemies across diverse regions in a bid to build a peaceful life."

"Ravenbound" is a single-player, open-world fantasy action game with fast-paced, roguelite-style combat and permadeath. As a vessel to the Raven, you must battle corrupted creatures and rebuild the Raven's power to free imprisoned Gods and restore order to the island of Ávalt. Despite stunning visuals and compelling music, the game is reported to be quite grinding and buggy.