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Active Immunity

Active Immunity Game Cover

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Active Immunity Game Cover

About Active Immunity

Active Immunity is a single player and multiplayer action game. It is being developed by Dylpickle Studios and will be released on October 30, 2026.

Something has slipped past the skin. You are what the body sends back. Active Immunity is a twin-stick bullet-hell roguelite fought inside the human body. Pick an immune cell, drop into infected tissue, and hold the line through 25 escalating waves of bacteria, viruses, fungi, parasites and worse. Weave through dense bullet patterns, stack upgrades into a build that feels unfair, and when the cam…

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Looking for games like Active Immunity? Here are top action recommendations, selected from player-similarity data — start with Beltrunner, System Cleaner or Pathogenic.

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Frequently Asked Questions

Active Immunity is a action game. Common tags for Active Immunity include science, indie, roguelite, 2d, bullet hell and others.

Active Immunity is available on PC, Windows and Linux.

Active Immunity is scheduled to be released on October 30, 2026.

Active Immunity was developed by Dylpickle Studios.

Active Immunity is a single player game with multiplayer and local co-op support.

Similar games include Beltrunner, System Cleaner, Pathogenic, Geometry Arena, Hyperspace Dogfights and others.